B6.Cg-Fbxw7tm1.1Axbe Foxm1tm1Rhc/H
| Status | Available to order |
| EMMA ID | EM:12633 |
| Citation information | RRID:IMSR_EM:12633 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Fbxw7tm1.1Axbe Foxm1tm1Rhc/H |
| Alternative name | Double Floxed Fbxw7/FoxM1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Foxm1tm1Rhc, Fbxw7tm1.1Axbe |
| Gene/Transgene symbol | Foxm1, Fbxw7 |
Information from provider
| Provider | Cancer Research UK |
| Provider affiliation | Ximbio, Cancer Research UK |
| Additional owner | Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, USA |
| Genetic information | Floxed Fbxw7 gene and floxed Foxm1 gene. We have initially generated the Fbxw7 fl/fl homozygous mice (floxed Fbxw7, see EMMA strain EM:12632) and these were interbred with the Foxm1 fl/fl homozygous mice (floxed-Foxm1), both in C57BL/6 background. Foxm1 fl/fl homozygous mice were kindly gifted by Dr. RH Costa (Gastroenterology. 2007 Apr;132(4):1420-31. & Proc Natl Acad Sci U S A, 99 2002, pp. 16881–16886). Different configuration of Fbxw7 and Foxm1 genes were verified by PCR analysis. |
| Phenotypic information | Homozygous:No overt phenotype, cre recombinase required for deletion of Fbxw7 and Foxm1.Heterozygous:No overt phenotype, cre recombinase required for deletion of Fbxw7 and Foxm1. |
| Breeding history | Backcrossed onto C57BL/6J for at least 5 generations. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |