IMPC phenotypes (gene matching)
C57BL/6J-Srsf6em2Gpb/H
| Status | Available to order |
| EMMA ID | EM:12634 |
| Citation information | RRID:IMSR_EM:12634 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6J-Srsf6em2Gpb/H |
| Alternative name | SRSF6 knock-out |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Srsf6em2Gpb |
| Gene/Transgene symbol | Srsf6 |
Information from provider
| Provider | Gillian Bates |
| Provider affiliation | Neurodegenerative Disease, UCL |
| Additional owner | We paid The Jackson Laboratory to generate the strain by CRISPR/Cas9 technology. In this instance The Jackson Lab. acted as a contract research organization (CRO) to generate mutant mice. The mice are not available from The Jackson Lab. |
| Genetic information | Srsf6 knock-out mice were generated at The Jackson Laboratory using CRISPR/Cas9. Guide RNAs were 5' to the transcription start site (TSS) and in intron 2 producing a deletion of 990 bp initiating 133 bp 5' of the TSS and 208 bp into intron 2. |
| Phenotypic information | Homozygous:Embryonic lethal.Heterozygous:No observable phenotype up to 12 months of age. The mice have not been phenotyped extensively in a quantitative manner. |
| Breeding history | The colony has been maintained by backcrossing Srsf6 knock-out heterozygous males to C57BL/6J females. Srsf6 knock-out homozygotes are embryonic lethal. |
| References | None available |
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |