C57BL/6NTac-Nfixem6(IMPC)H/H

Status

Available to order

EMMA IDEM:12649
Citation informationRRID:IMSR_EM:12649 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Nfixem6(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolNfixem6(IMPC)H
Gene/Transgene symbolNfix

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • delayed bone ossification / MGI
  • decreased compact bone thickness / MGI
  • abnormal vertebral body morphology / MGI
  • kyphosis / MGI
  • scoliosis / MGI
  • lordosis / MGI
  • abnormal long bone hypertrophic chondrocyte zone / MGI
  • megacephaly / MGI
  • domed cranium / MGI
  • abnormal small intestine morphology / MGI
  • abnormal corpus callosum morphology / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal dentate gyrus morphology / MGI
  • dilated lateral ventricles / MGI
  • dilated third ventricle / MGI
  • weight loss / MGI
  • decreased body size / MGI
  • delayed eyelid opening / MGI
  • ataxia / MGI
  • limb grasping / MGI
  • hydroencephaly / MGI
  • abnormal craniofacial bone morphology / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • increased brain weight / MGI
  • abnormal inner ear canal morphology / MGI
  • abnormal cranial suture morphology / MGI
  • abnormal bone mineralization / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • delayed endochondral bone ossification / MGI
  • abnormal long bone epiphyseal plate proliferative zone / MGI
  • abnormal intervertebral disk morphology / MGI
  • abnormal spine curvature / MGI
  • intervertebral disk degeneration / MGI
  • abnormal timing of postnatal eyelid opening / MGI
  • craniofacial phenotype / MGI
  • increased long bone epiphyseal plate size / MGI
  • abnormal hippocampus CA1 region morphology / MGI
  • slow postnatal weight gain / MGI
  • enlarged lateral ventricles / MGI
  • decreased trabecular bone thickness / MGI
  • decreased trabecular bone mass / MGI
  • lethality at weaning, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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