IMPC phenotypes (allele matching)
C57BL/6NTac-Irs1em1(IMPC)H/H
| Status | Available to order |
| EMMA ID | EM:12668 |
| Citation information | RRID:IMSR_EM:12668 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Irs1em1(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Irs1em1(IMPC)H |
| Gene/Transgene symbol | Irs1 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- decreased compact bone thickness / MGI
- abnormal long bone hypertrophic chondrocyte zone / MGI
- decreased chondrocyte number / MGI
- decreased circulating HDL cholesterol level / MGI
- hypertension / MGI
- decreased cell proliferation / MGI
- abnormal femur morphology / MGI
- thin tail / MGI
- short tail / MGI
- decreased body length / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal osteoclast physiology / MGI
- abnormal lipid level / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- postnatal growth retardation / MGI
- abnormal glucose homeostasis / MGI
- increased circulating insulin level / MGI
- postnatal lethality / MGI
- premature death / MGI
- abnormal postnatal growth/weight/body size / MGI
- abnormal tail morphology / MGI
- short tibia / MGI
- abnormal bone mineralization / MGI
- abnormal bone healing / MGI
- decreased insulin secretion / MGI
- short femur / MGI
- abnormal long bone epiphyseal plate proliferative zone / MGI
- abnormal bone structure / MGI
- fetal growth retardation / MGI
- abnormal vascular wound healing / MGI
- increased osteoclast cell number / MGI
- increased osteoblast cell number / MGI
- decreased osteoblast cell number / MGI
- abnormal osteoblast physiology / MGI
- abnormal cell differentiation / MGI
- abnormal pancreatic beta cell morphology / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- homeostasis/metabolism phenotype / MGI
- skeleton phenotype / MGI
- decreased percent body fat/body weight / MGI
- decreased circulating glucose level / MGI
- decreased vasodilation / MGI
- increased systemic arterial diastolic blood pressure / MGI
- increased systemic arterial systolic blood pressure / MGI
- decreased long bone epiphyseal plate size / MGI
- impaired lipolysis / MGI
- abnormal osteoclast differentiation / MGI
- proportional dwarf / MGI
- decreased trabecular bone thickness / MGI
- decreased fetal weight / MGI
- decreased birth weight / MGI
- decreased total body fat amount / MGI
- decreased bone mineral content / MGI
- mortality/aging / MGI
- impaired osteoblast differentiation / MGI
- increased or absent threshold for auditory brainstem response / MGI
- decreased osteoblast proliferation / MGI