strain-details - INFRAFRONTIER

Information from provider

Status	Under development - register interest
EMMA ID	EM:12696
Citation information	RRID:IMSR_EM:12696 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NCrl-Klhl6^{em1(IMPC)Ccpcz}/Ph
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Klhl6^{em1(IMPC)Ccpcz}
Gene/Transgene symbol	Klhl6

Provider	Institute of Molecular Genetics
Provider affiliation	Department of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Disease and phenotype information

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

Orphanet associated rare diseases, based on orthologous gene matching

Cold-induced sweating syndrome / Orphanet_157820
Retinitis pigmentosa / Orphanet_791
Bohring-Opitz syndrome / Orphanet_97297
KLHL7-related Bohring-Opitz-like syndrome / Orphanet_603689

IMPC phenotypes (allele matching)

abnormal heart morphology / IMPC
enlarged heart / IMPC
abnormal spleen morphology / IMPC
small spleen / IMPC
abnormal thymus morphology / IMPC
enlarged thymus / IMPC
abnormal testis morphology / IMPC
small testis / IMPC
small seminal vesicle / IMPC
abnormal lung morphology / IMPC
abnormal pancreas morphology / IMPC
abnormal seminal vesicle morphology / IMPC
abnormal kidney morphology / IMPC
abnormal inspiratory capacity / IMPC
enlarged kidney / IMPC
enlarged pancreas / IMPC
decreased eosinophil cell number / IMPC
increased T cell number / IMPC
increased CD4-positive, alpha-beta T cell number / IMPC
increased CD8-positive, alpha-beta T cell number / IMPC
decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
increased CD8-positive, naive alpha-beta T cell number / IMPC
increased T-helper cell number / IMPC
decreased effector memory T-helper cell number / IMPC

IMPC phenotypes (gene matching)

increased CD4-positive, alpha-beta T cell number / IMPC
abnormal seminal vesicle morphology / IMPC
abnormal testis morphology / IMPC
abnormal thymus morphology / IMPC
small seminal vesicle / IMPC
abnormal heart morphology / IMPC
abnormal spleen morphology / IMPC
enlarged thymus / IMPC
enlarged heart / IMPC
abnormal pancreas morphology / IMPC
increased T cell number / IMPC
abnormal lung morphology / IMPC
abnormal kidney morphology / IMPC
enlarged kidney / IMPC
decreased effector memory T-helper cell number / IMPC
abnormal inspiratory capacity / IMPC
decreased eosinophil cell number / IMPC
small spleen / IMPC
small testis / IMPC
increased T-helper cell number / IMPC
increased CD8-positive, naive alpha-beta T cell number / IMPC
increased CD8-positive, alpha-beta T cell number / IMPC
decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
enlarged pancreas / IMPC

MGI phenotypes (gene matching)

abnormal spleen morphology / MGI
spleen hypoplasia / MGI
abnormal B cell differentiation / MGI
abnormal adaptive immunity / MGI
decreased spleen weight / MGI
increased T cell number / MGI
decreased B cell number / MGI
increased CD4-positive, alpha beta T cell number / MGI
decreased CD8-positive, alpha-beta T cell number / MGI
increased single-positive T cell number / MGI
increased B-1b cell number / MGI
decreased follicular B cell number / MGI
decreased mature B cell number / MGI
increased immature B cell number / MGI
abnormal lymph node germinal center morphology / MGI
decreased central memory CD4-positive, alpha-beta T cell number / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

C57BL/6NCrl-Klhl6^{em1(IMPC)Ccpcz}/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Klhl6em1(IMPC)Ccpcz/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Klhl6^{em1(IMPC)Ccpcz}/Ph