IMPC phenotypes (gene matching)
C57BL/6-Csf2rbtm1c(EUCOMM)Hmgu/Orl
| Status | Available to order |
| EMMA ID | EM:12699 |
| Citation information | RRID:IMSR_EM:12699 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Csf2rbtm1c(EUCOMM)Hmgu/Orl |
| Alternative name | C57BL/6N-Csf2rbtm1c(EUCOMM)Hmgu |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Csf2rbtm1c(EUCOMM)Hmgu |
| Gene/Transgene symbol | Csf2rb |
Information from provider
| Provider | Burkhard Becher |
| Provider affiliation | Institute of experimental Immunology, University of Zurich |
| Genetic information | This mouse strain was generated in the laboratory of Dr. Burkhard Becher at the University of Zürich. The L1L2_Bact_P cassette was inserted at position 78337719 of Chromosome 15 upstream of exon 4 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 4 at position 78339575. The construct was electroporated into C57BL/6N-Atm1Brd-derived JM8A3.N1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts. The resulting chimeric animals were bred to C57BL/6-Tg(CAG-flpe)2Arte, a strain which ubiquitously expresses the flp recombinase. Upon arrival, mice were bred to C57BL/6NJ (JAX Mice Stock No. 005304) for at least 1 generation to establish the colony. |
| Phenotypic information | Homozygous:Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any physical or behavioral abnormalities. Heterozygous:Mice that are heterozygous for this allele are viable, fertile, normal in size and do not display any physical or behavioral abnormalities. |
| Breeding history | More than 100 mice, litter size is normal compared to wild-type; all genotypes are viable and fertile. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6N males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hereditary pulmonary alveolar proteinosis / Orphanet_264675
Literature references
- The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.;Croxford Andrew L, Lanzinger Margit, Hartmann Felix J, Schreiner Bettina, Mair Florian, Pelczar Pawel, Clausen Björn E, Jung Steffen, Greter Melanie, Becher Burkhard, ;2015;Immunity;43;502-14; 26341401
- GM-CSF-dependent CD301b+ lung dendritic cells confer tolerance to inhaled allergens.;Wilkinson Christina L, Nakano Keiko, Grimm Sara A, Whitehead Gregory S, Arao Yukitomo, Blackshear Perry J, Karmaus Peer W, Fessler Michael B, Cook Donald N, Nakano Hideki, ;2024;Research square;0;; 38883724