Sprague Dawley rat Rno1_Del(Sult1a1-Spn) X Rno1_Dup(Sult1a1-Spn)/YahIcsOrl

Status	Available to order
EMMA ID	EM:12851
Citation information	EM:12851
International strain name	Sprague Dawley rat Rno1_Del(Sult1a1-Spn) X Rno1_Dup(Sult1a1-Spn)/YahIcsOrl
Alternative name	Sprague Dawley rat Rno1_Del(Sult1a1-Spn) X Rno1_Dup(Sult1a1-Spn)
Strain type	Endonuclease-mediated
Allele/Transgene symbol	rat Sult1a-Spn
Gene/Transgene symbol	rat Sult1a-Spn

Information from provider

Provider	Yann Herault
Provider affiliation	Translational Medicine and Neurogenetics, IGBMC
Genetic information	Sprague Dawley rat. Cross between EM:11821 and EM:11822. EM:11821: Deletion of the genetic interval Sult1a1-Spn: we targeted an extended sequence of the whole locus from one allele and the CRISPR/Cas9 system allowed us to remove the region encompassing 28 genes, orthologous to human. EM:11822: Tandem duplication of the genetic interval between Sult1a1 and Spn genes using CRISPR/Cas9 engineering. We targeted the genetic interval borders from one allele and the CRISPR/Cas9 system allowed us to cut and transpose those sequences to the same locus on the second allele.
Phenotypic information	Homozygous: Not Known Heterozygous: Under investigation
Breeding history	Backcross on Sprague Dawley background.
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	heterozygous rat Sprague-Dawley males, wild-type rat Sprague-Dawley females
Stage of embryos	2-cell

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
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