B6J.129S2-Roratm1.1Ics/Ics

Status

Available to order

EMMA IDEM:12934
Citation informationRRID:IMSR_EM:12934 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6J.129S2-Roratm1.1Ics/Ics
Alternative nameRORa CM
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolRoratm1.1Ics
Gene/Transgene symbolRora

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
NA

Heterozygous:
NA
Breeding history7 backcross generations
References
  • RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis.;Han Yong-Hyun, Kim Hyeon-Ji, Na Hyelin, Nam Min-Woo, Kim Ju-Yeon, Kim Jun-Seok, Koo Seung-Hoi, Lee Mi-Ock, ;2017;Cell reports;20;124-135; 28683306
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased circulating alkaline phosphatase level / IMPC
  • preweaning lethality, incomplete penetrance / IMPC

Literature references

  • RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis.;Han Yong-Hyun, Kim Hyeon-Ji, Na Hyelin, Nam Min-Woo, Kim Ju-Yeon, Kim Jun-Seok, Koo Seung-Hoi, Lee Mi-Ock, ;2017;Cell reports;20;124-135; 28683306
  • The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow.;Abe Shinya, Kagao Moe, Asahi Takuma, Kato Ryoma, Tani-Ichi Shizue, Shimba Akihiro, Ishibashi Riki, Miyachi Hitoshi, Kitano Satsuki, Miyazaki Masaki, Rodewald Hans-Reimer, Toyoshima Fumiko, Ikuta Koichi, ;2025;Journal of immunology (Baltimore, Md. : 1950);0;; 40079843

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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