C57BL/6NCrl-Ccr1em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:13051
Citation informationRRID:IMSR_EM:13051 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NCrl-Ccr1em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolCcr1em1(IMPC)Ccpcz
Gene/Transgene symbolCcr1

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

MGI phenotypes (gene matching)
  • decreased mast cell number / MGI
  • altered response to myocardial infarction / MGI
  • impaired hematopoiesis / MGI
  • lung inflammation / MGI
  • decreased airway responsiveness / MGI
  • decreased susceptibility to viral infection / MGI
  • decreased susceptibility to bacterial infection / MGI
  • abnormal macrophage physiology / MGI
  • abnormal neutrophil physiology / MGI
  • granulomatous inflammation / MGI
  • glomerulonephritis / MGI
  • increased urine protein level / MGI
  • abnormal leukocyte adhesion / MGI
  • increased length of allograft survival / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • increased susceptibility to parasitic infection / MGI
  • glomerulosclerosis / MGI
  • abnormal renal glomerulus morphology / MGI
  • immune system phenotype / MGI
  • increased susceptibility to fungal infection / MGI
  • increased blood urea nitrogen level / MGI
  • decreased susceptibility to type III hypersensitivity reaction / MGI
  • increased susceptibility to type IV hypersensitivity reaction / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • abnormal Kupffer cell morphology / MGI
  • increased IgG2a level / MGI
  • increased tumor necrosis factor secretion / MGI
  • decreased tumor necrosis factor secretion / MGI
  • increased interferon-gamma secretion / MGI
  • decreased circulating interferon-gamma level / MGI
  • decreased interleukin-10 secretion / MGI
  • increased interleukin-12 secretion / MGI
  • decreased interleukin-13 secretion / MGI
  • impaired neutrophil recruitment / MGI
  • abnormal chemokine secretion / MGI
  • cecum inflammation / MGI
  • decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal cellular extravasation / MGI
  • abnormal circulating chemokine level / MGI
  • increased macrophage nitric oxide production / MGI
  • glomerular crescent / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

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    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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