B6.Cg-Trp73tm1Gml/H
| Status | Available to order |
| EMMA ID | EM:13067 |
| International strain name | B6.Cg-Trp73tm1Gml/H |
| Alternative name | Trp73fl/fl (Trp73 flox/flox) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Trp73tm1Gml, |
| Gene/Transgene symbol | Trp73 |
Information from provider
| Provider | Gerry Melino |
| Provider affiliation | MRC Toxicology Unit |
| Genetic information | This is the floxed strain used for the generation of Trp73D13/D13 strain (EMMA strain EM:13068). Floxed (Trp73fl/fl) mice were obtained by introducing a vector containing loxP sites flanking exon 13 of the Trp73 gene, which was replaced by a neoR cassette to enable selection. Immediately upstream and downstream of these sites, long terminal repeats (LTRs) facilitated incorporation of the vector into ES cells by homologous recombination. |
| Phenotypic information | Homozygous:No abnormalitiesHeterozygous:No abnormalities |
| Breeding history | Backcrossed more than 10 generations |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- The C terminus of p73 is essential for hippocampal development.;Amelio Ivano, Panatta Emanuele, Niklison-Chirou Maria Victoria, Steinert Joern R, Agostini Massimiliano, Morone Nobuhiro, Knight Richard A, Melino Gerry, ;2020;Proceedings of the National Academy of Sciences of the United States of America;117;15694-15701; 32571922
- P73 C-terminus is dispensable for multiciliogenesis.;Buckley Niall, Panatta Emanuele, Morone Nobuhiro, Noguchi Masafumi, Scorrano Luca, Knight Richard A, Amelio Ivano, Melino Gerry, ;2020;Cell cycle (Georgetown, Tex.);19;1833-1845; 32584647