IMPC phenotypes (gene matching)
B6.129P2-Trp73tm1Mak/H
| Status | Available to order |
| EMMA ID | EM:13070 |
| Citation information | RRID:IMSR_EM:13070 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Trp73tm1Mak/H |
| Alternative name | TAp73-/- |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Trp73tm1Mak |
| Gene/Transgene symbol | Trp73 |
Information from provider
| Provider | Gerry Melino |
| Provider affiliation | MRC Toxicology Unit |
| Additional owner | Prof. Tak Mak, University of Toronto, Canada |
| Genetic information | Mutant mice deficient for Trp73 exons 2 and 3, which are specific for the TAp73 isoforms, were generated by conventional gene targeting procedures in 129/SvOla embryonic stem cells. Blastocysts were transferred to pseudopregnant C57BL/6J female mice. TAp73 wild-type (+/+; TAp73), heterozygous (+/-; TAp73+/-), and homozygous (-/-; TAp73) littermate mice (129/SvOla × C57BL/6J) were generated by intercrossing TAp73+/- mice (Genes Dev., 2008 Oct 1;22(19):2677-91. doi: 10.1101/gad.1695308). |
| Phenotypic information | Homozygous:A percentage of TAp73-/- mice die during embryogenesis, resulting in an abnormal Mendelian ratio at birth (+/+, 29%; +/-, 52%; -/- 19%). Unable to obtain pups from mating trials involving mating a TAp73-/- male or female with wild-type mice. No oocytes were present in the fallopian tubes of TAp73-/- females 16 h after administration of hCG. The ovulated oocytes were trapped under the bursa and did not progress toward the fallopian tubes. TAp73-/- mice show hippocampal dysgenesis; the lower blade of the dentate gyrus was either completely missing or greatly truncated. 73% of TAp73 mice of a mixed genetic background spontaneously developed malignancies (Fig. 5B,C in Genes Dev., 2008;22(19):2677-91). Lung adenocarcinoma was the most frequent cancer that developed in TAp73 -/-mice, being observed in 32% of all TAp73 mice analysed and representing 44% of all tumours excised from TAp73 -/- mice (Genes Dev., 2008 Oct 1;22(19):2677-91. doi: 10.1101/gad.1695308). Heterozygous:No abnormal phenotype is observed in heterozygous mice (compared to wild-type littermate) |
| Breeding history | Backcrossed for more than 10 generations. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- absent Cajal-Retzius cell / MGI
- domed cranium / MGI
- gastrointestinal hemorrhage / MGI
- absent enterocytes / MGI
- excessive digestive secretion / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal cortical marginal zone morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal hippocampus development / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal choroid plexus morphology / MGI
- dilated lateral ventricles / MGI
- abnormal hypothalamus morphology / MGI
- abnormal trigeminal ganglion morphology / MGI
- decreased body size / MGI
- submission towards male mice / MGI
- reduced male mating frequency / MGI
- abnormal embryo development / MGI
- periorbital edema / MGI
- increased susceptibility to otitis media / MGI
- conjunctivitis / MGI
- rhinitis / MGI
- sinus inflammation / MGI
- hydroencephaly / MGI
- non-obstructive hydrocephaly / MGI
- abnormal cerebrospinal fluid production / MGI
- intracranial hemorrhage / MGI
- intraventricular hemorrhage / MGI
- reduced fertility / MGI
- male infertility / MGI
- female infertility / MGI
- abnormal ovulation / MGI
- neoplasm / MGI
- increased cellular sensitivity to gamma-irradiation / MGI
- increased malignant tumor incidence / MGI
- increased tumor incidence / MGI
- increased T cell derived lymphoma incidence / MGI
- increased lung adenocarcinoma incidence / MGI
- increased carcinoma incidence / MGI
- increased lung adenoma incidence / MGI
- premature death / MGI
- neurodegeneration / MGI
- abnormal vomeronasal organ morphology / MGI
- increased susceptibility to bacterial infection / MGI
- chronic inflammation / MGI
- abnormal hippocampal mossy fiber morphology / MGI
- abnormal cell cycle / MGI
- increased neuron apoptosis / MGI
- abnormal forebrain development / MGI
- increased hemangiosarcoma incidence / MGI
- maternal effect / MGI
- abnormal chromosome number / MGI
- polyploidy / MGI
- increased incidence of tumors by chemical induction / MGI
- cachexia / MGI
- abnormal female meiosis / MGI
- decreased oocyte number / MGI
- decreased Cajal-Retzius cell number / MGI
- abnormal dendrite morphology / MGI
- abnormal hippocampus CA3 region morphology / MGI
- anovulation / MGI
- abnormal ovarian follicle number / MGI
- increased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced cell death / MGI
- decreased neuron number / MGI
- distended ileum / MGI
- increased thymocyte apoptosis / MGI
- abnormal meiotic spindle morphology / MGI
- abnormal hippocampus neuron morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- increased lymphoma incidence / MGI
Literature references
- TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.;Tomasini Richard, Tsuchihara Katsuya, Wilhelm Margareta, Fujitani Masashi, Rufini Alessandro, Cheung Carol C, Khan Fatima, Itie-Youten Annick, Wakeham Andrew, Tsao Ming-Sound, Iovanna Juan L, Squire Jeremy, Jurisica Igor, Kaplan David, Melino Gerry, Jurisicova Andrea, Mak Tak W, ;2008;Genes & development;22;2677-91; 18805989