C3HeB/FeJ-Psmb10Tub6/Ieg
| Status | Available to order |
| EMMA ID | EM:13077 |
| International strain name | C3HeB/FeJ-Psmb10Tub6/Ieg |
| Alternative name | TUB006 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Psmb10Tub6, |
| Gene/Transgene symbol | Psmb10 |
Information from provider
| Provider | Martin Hrabe de Angelis |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum München |
| Additional owner | Prof. Dr. Busch, Dirk, Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, TUM, Munich, Germany |
| Genetic information | G->T point mutation on chromosome 8 (position Chr8:108459981). The point mutation is located in exon 7 of Psmb10 and leads to an amino acid exchange from glycine to tryptophan at position 170 of the mature MECL-1 protein. From the different backgrounds mentioned in this ref. "https://pubmed.ncbi.nlm.nih.gov/29654304/" the one available from EMMA is C3HeB/FeJ. |
| Phenotypic information | Homozygous:Homozygous TUB6 mice exhibit a lethal immunological phenotype comprising SCID and systemic inflammation.Heterozygous:In heterozygous TUB6 mice, a selective T cell defect was observed, with a substantially reduced T cell compartment at baseline conditions and failure of developing a protective antigen-specific T cell response to L.m. infection. |
| Breeding history | Unknown number of backcrosses |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C3HeB/FeJ |
Literature references
- Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.;Treise Irina, Huber Eva M, Klein-Rodewald Tanja, Heinemeyer Wolfgang, Grassmann Simon A, Basler Michael, Adler Thure, Rathkolb Birgit, Helming Laura, Andres Christian, Klaften Matthias, Landbrecht Christina, Wieland Thomas, Strom Tim M, McCoy Kathy D, Macpherson Andrew J, Wolf Eckhard, Groettrup Marcus, Ollert Markus, Neff Frauke, Gailus-Durner Valerie, Fuchs Helmut, Hrabě de Angelis Martin, Groll Michael, Busch Dirk H, ;2018;Scientific reports;8;5975; 29654304