STOCK Svbpem1Flmg/Flmg
| Status | Available to order |
| EMMA ID | EM:13078 |
| Citation information | RRID:IMSR_EM:13078 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Svbpem1Flmg/Flmg |
| Alternative name | SVBP mutant |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Svbpem1Flmg |
| Gene/Transgene symbol | Svbp |
Information from provider
| Provider | Transgenics Facility B.S.R.C |
| Provider affiliation | B.S.R.C. "Alexander Fleming |
| Genetic information | Mice with a 305 bp deletion of the Svbp gene were generated using CRISPR/Cas9 technology. This deletion includes the last 37 bp of exon 2 and the first 192 bp of intron 2. Two guide sgRNAs along with Cas9 D10A nickase were introduced into mouse zygotes via pronuclear microinjections. |
| Phenotypic information | Homozygous:Not knownHeterozygous:No observable phenotype up to 10 months of age. The mice have not been phenotyped extensively in a quantitative manner. |
| Breeding history | The colony has been maintained by backcrossing Svbp knock-out heterozygous mice to C57BL/6J mice for two generations. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6 x CBA males, wild-type C57BL/6J females |
| Stage of embryos | Morula |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084