STOCK Loxl3tm1a(EUCOMM)Wtsi/Cnbc

Status

Available to order

EMMA IDEM:13124
Citation informationRRID:IMSR_EM:13124 

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International strain nameSTOCK Loxl3tm1a(EUCOMM)Wtsi/Cnbc
Alternative nameAPC
Strain typeTargeted Mutant Strains
Allele/Transgene symbolLoxl3tm1a(EUCOMM)Wtsi
Gene/Transgene symbolLoxl3

Information from provider

ProviderFrancisco Portillo
Provider affiliationBiochemistry, Universidad Autonoma de Madrid
Additional ownerAmparo Cano and Patricia G Santamaria, Universidad Autónoma de Madrid, Madrid, Spain
Genetic informationTargeted mutation in the Loxl3 gene. ES cell clones containing a targeted mutation of Loxl3 (Loxl3tm1a(EUCOMM)Wtsi, conditional ready, null/knockout, reporter - cre recombinase/loxP system) were obtained from the EUCOMM repository.
Phenotypic informationHomozygous:
Partial perinatal lethality due to osteo-articular defects.

Heterozygous:
None
Breeding historyES clones cells containing a targeted mutation of Loxl3 (Loxl3tm1a(EUCOMM)Wtsi, conditional ready, null/knockout, reporter - cre recombinase/loxP system) were obtained from the EUCOMM repository. Heterozygous animals were intercrossed to obtain homozygous animals.
References
  • Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development.;Santamaría Patricia G, Dubus Pierre, Bustos-Tauler José, Floristán Alfredo, Vázquez-Naharro Alberto, Morales Saleta, Cano Amparo, Portillo Francisco, ;2022;International journal of molecular sciences;23;; 35628534
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous mixed males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • short mandible / MGI
  • abnormal vomer bone morphology / MGI
  • cleft palate / MGI
  • abnormal vertebral body morphology / MGI
  • abnormal craniofacial morphology / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • no phenotypic analysis / MGI
  • abnormal chest morphology / MGI
  • abnormal spine curvature / MGI
  • abnormal vertebral column morphology / MGI
  • abnormal vertebral body development / MGI
  • cardiovascular system phenotype / MGI
  • respiratory system phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal palate development / MGI
  • failure of palatal shelf elevation / MGI
  • palatal shelves fail to meet at midline / MGI
  • integument phenotype / MGI
  • postnatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI

Literature references

  • Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development.;Santamaría Patricia G, Dubus Pierre, Bustos-Tauler José, Floristán Alfredo, Vázquez-Naharro Alberto, Morales Saleta, Cano Amparo, Portillo Francisco, ;2022;International journal of molecular sciences;23;; 35628534

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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