| Status | Under development - register interest |
| EMMA ID | EM:13140 |
| Citation information | RRID:IMSR_EM:13140 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Ifnar1tm1Agt/Cnrm |
| Alternative name | IFNAR |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ifnar1tm1Agt |
| Gene/Transgene symbol | Ifnar1 |
| Provider | Eleonora Aricò |
| Provider affiliation | Core Facilities, Istituto Superiore di Sanità |
| Genetic information | Mice are homozygous for the knocked out gene encoding interferon alpha/beta receptor 1. |
| Phenotypic information | Homozygous:Homozygotes Ifnar1 (IFNAR) knock-out mice lack type I interferon receptor function and are viable, fertile and phenotypically normal but show increased susceptibility to viral infections and diminished cancer immune surveillance. Heterozygous:Heterozygous Ifnar1 (IFNAR) knock-out mice are viable, fertile and phenotypically normal. No data are available on their susceptibility to viral infections. |
| Breeding history | 129/Sv Ifnar1-/- female mice (A129; Muller et al., Science, 1994) were originally purchased from B&K Universal LTD, UK (now Marshall BioResoures, US). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Breeding at archiving centre | 1 backcross to C57BL/6N |
