MGI phenotypes (allele matching)
B6.129-Hint1tm1Ibw/Orl
| Status | Available to order |
| EMMA ID | EM:13222 |
| International strain name | B6.129-Hint1tm1Ibw/Orl |
| Alternative name | Hint1 KO C57BL/6J |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Hint1tm1Ibw, |
| Gene/Transgene symbol | Hint1 |
Information from provider
| Provider | Jean-François Dufour |
| Provider affiliation | BioMedical Research DBMR, University of Bern |
| Additional owner | Hint1 strain was a gift from Prof. Weinstein, NY USA. |
| Genetic information | This strain was obtained by crossing the heterozygous Hint1 knock-out strain for over 10 generation with C57BL/6J. |
| Phenotypic information | Homozygous:When homozygous, Hint1 knock-out mice show higher incidence in tumours.Heterozygous:Hint1 is a haplo-insufficient tumour suppressor. |
| Breeding history | Hint1 knock-out: ES cells that were heterozygous for the targeted mutation were microinjected into C57BL/6 blastocysts and implanted into pseudopregnant females. The resulting male chimeras were mated with female C57BL/6 mice. Germ-line transmission of the injected ES cells was confirmed by inheritance of the agouti coat color in F1 mice, and the agouti offspring were tested for the presence of the mutated Hint1 allele by Southern blot analysis of mouse tail DNA. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J, wild-type C57BL/6J |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive axonal neuropathy with neuromyotonia / Orphanet_324442
Literature references
- Hint1 is a haplo-insufficient tumor suppressor in mice.;Li H, Zhang Y, Su T, Santella R M, Weinstein I B, ;2006;Oncogene;25;713-21; 16186798
- Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis.;Su Tao, Suzui Masumi, Wang Lei, Lin Chyuan-Sheng, Xing Wang-Qiu, Weinstein I Bernard, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;7824-9; 12810953
- Ablation of the tumor suppressor histidine triad nucleotide binding protein 1 is protective against hepatic ischemia/reperfusion injury.;Martin Juliette, Romanque Pamela, Maurhofer Olivier, Schmitter Karin, Hora Caroline, Ferrand Gisèle, Dufour Jean-François, ;2011;Hepatology (Baltimore, Md.);53;243-52; 21140474
- Disruption of tumor suppressor gene Hint1 leads to remodeling of the lipid metabolic phenotype of mouse liver.;Beyoğlu Diren, Krausz Kristopher W, Martin Juliette, Maurhofer Olivier, Dorow Juliane, Ceglarek Uta, Gonzalez Frank J, Dufour Jean-François, Idle Jeffrey R, ;2014;Journal of lipid research;55;2309-19; 25193995