C57BL/6NTac-Bcl2l11em1(IMPC)H/H

Status

Available to order

EMMA IDEM:13267
Citation informationRRID:IMSR_EM:13267 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Bcl2l11em1(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolBcl2l11em1(IMPC)H
Gene/Transgene symbolBcl2l11

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased leukocyte cell number / IMPC
  • increased erythrocyte cell number / IMPC
  • increased spleen weight / IMPC
  • increased lymphocyte cell number / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • increased circulating potassium level / IMPC
  • decreased total body fat amount / IMPC
  • increased grip strength / IMPC
  • increased large unstained cell number / IMPC
IMPC phenotypes (gene matching)
  • increased lymphocyte cell number / IMPC
  • increased grip strength / IMPC
  • increased large unstained cell number / IMPC
  • increased spleen weight / IMPC
  • increased erythrocyte cell number / IMPC
  • increased leukocyte cell number / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • decreased total body fat amount / IMPC
  • increased circulating potassium level / IMPC
MGI phenotypes (gene matching)
  • increased leukocyte cell number / MGI
  • increased monocyte cell number / MGI
  • increased granulocyte number / MGI
  • abnormal mammary gland development / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal sympathetic neuron morphology / MGI
  • increased inflammatory response / MGI
  • vasculitis / MGI
  • premature death / MGI
  • abnormal kidney morphology / MGI
  • no abnormal phenotype detected / MGI
  • gliosis / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal plasma cell morphology / MGI
  • abnormal B cell physiology / MGI
  • increased immunoglobulin level / MGI
  • increased IgG level / MGI
  • increased IgM level / MGI
  • increased IgA level / MGI
  • dilated renal tubules / MGI
  • glomerulonephritis / MGI
  • no phenotypic analysis / MGI
  • thrombocytopenia / MGI
  • nervous system phenotype / MGI
  • increased autoantibody level / MGI
  • abnormal lymphocyte physiology / MGI
  • abnormal CD8-positive, alpha-beta T cell physiology / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-single stranded DNA antibody level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • increased anti-histone antibody level / MGI
  • abnormal B cell morphology / MGI
  • increased spleen weight / MGI
  • increased regulatory T cell number / MGI
  • increased B cell number / MGI
  • increased T cell number / MGI
  • decreased lymphocyte cell number / MGI
  • abnormal response to infection / MGI
  • abnormal NK cell morphology / MGI
  • increased double-negative T cell number / MGI
  • decreased double-positive T cell number / MGI
  • abnormal B cell proliferation / MGI
  • abnormal renal glomerulus morphology / MGI
  • increased susceptibility to autoimmune disorder / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal leukopoiesis / MGI
  • increased blood urea nitrogen level / MGI
  • decreased apoptosis / MGI
  • abnormal involution of the mammary gland / MGI
  • decreased T cell apoptosis / MGI
  • increased NK cell number / MGI
  • abnormal CD4-positive, alpha beta T cell number / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • increased follicular B cell number / MGI
  • increased marginal zone B cell number / MGI
  • increased transitional stage B cell number / MGI
  • increased B-2 B cell number / MGI
  • increased mature B cell number / MGI
  • increased immature B cell number / MGI
  • decreased B cell apoptosis / MGI
  • abnormal splenic cell ratio / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased splenocyte number / MGI
  • abnormal mammary gland duct morphology / MGI
  • decreased thymocyte apoptosis / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • abnormal renal glomerulus basement membrane morphology / MGI
  • expanded mesangial matrix / MGI
  • increased renal glomerulus apoptosis / MGI
  • renal cast / MGI
  • glomerular crescent / MGI
  • increased fibroblast apoptosis / MGI
  • renal glomerular immunoglobulin deposits / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).