IMPC phenotypes (gene matching)
- abnormal posture / IMPC
B6.Cg-Gt(ROSA)26Sortm(rtTA) Col1a1tm1(tetO-Cpt1a,-GFP)Slms/Cnbc
| Status | Available to order |
| EMMA ID | EM:13349 |
| Citation information | RRID:IMSR_EM:13349 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Gt(ROSA)26Sortm(rtTA) Col1a1tm1(tetO-Cpt1a,-GFP)Slms/Cnbc |
| Alternative name | R26-rtTAtg/0:tetO-Cpt1atg/0 (R26rtTA-CPT1A) |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Col1a1tm1(tetO-Cpt1a,-GFP)Slms, Gt(ROSA)26Sortm(rtTA) |
| Gene/Transgene symbol | Col1a1, Gt(ROSA)26Sor |
Information from provider
| Provider | Santiago Lamas |
| Provider affiliation | Procesos Fisiológicos y Patológicos, Centro de Biología Molecular Severo Ochoa |
| Genetic information | R26-rtTA cassette (Gt(ROSA)26Sor locus): ubiquitous expression of rtTA. TRE-CPT1A-P2A-GFP cassette (Col1a1 locus): CPT1A and GFP coding sequence under the control of the TRE element. P2A allows the protein excision among CPT1A and GFP. The TRE-CPT1A-PA2A-GFP cassette (minimal CMV promoter) contained in a pBS31 vector was inserted downstream of the Col1a1 locus by FRT/flippase-mediated recombination. |
| Phenotypic information | Homozygous:Phenotypically undistinguishable from wild-type mice. No anatomical anomalies, physiological variations, behavioural abnormalities or food uptake alterations. Heterozygous:No phenotypic alterations. Mice present a CPT1A overexpression and enhanced fatty acid oxidation ubiquitous. |
| Breeding history | R26-rtTA, tetO-CPT1A mice (B6N;129Sv background) were backcrossed to C57BL/6J mice for at least 5 generations to generate this congenic strain. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Ehlers-Danlos/osteogenesis imperfecta syndrome / Orphanet_230857
- Osteogenesis imperfecta type 3 / Orphanet_216812
- Arthrochalasia Ehlers-Danlos syndrome / Orphanet_1899
- Classical Ehlers-Danlos syndrome / Orphanet_287
- Osteogenesis imperfecta type 2 / Orphanet_216804
- Osteogenesis imperfecta type 4 / Orphanet_216820
- Caffey disease / Orphanet_1310
- High bone mass osteogenesis imperfecta / Orphanet_314029
- Osteogenesis imperfecta type 1 / Orphanet_216796
MGI phenotypes (gene matching)
- abnormal adipose tissue distribution / MGI
- big ears / MGI
- delayed bone ossification / MGI
- fragile skeleton / MGI
- increased bone mineral density / MGI
- decreased bone mineral density / MGI
- failure of bone resorption / MGI
- osteopetrosis / MGI
- kyphoscoliosis / MGI
- abnormal neurocranium morphology / MGI
- decreased compact bone thickness / MGI
- abnormal vertebral body morphology / MGI
- abnormal rib morphology / MGI
- kyphosis / MGI
- scoliosis / MGI
- heart right ventricle hypertrophy / MGI
- increased cell proliferation / MGI
- abnormal cell morphology / MGI
- focal hair loss / MGI
- abnormal cranium morphology / MGI
- abnormal maxilla morphology / MGI
- abnormal digestive system morphology / MGI
- abnormal forelimb morphology / MGI
- abnormal femur morphology / MGI
- syndactyly / MGI
- oligodactyly / MGI
- abnormal autopod morphology / MGI
- thin tail / MGI
- abnormal liver morphology / MGI
- weakness / MGI
- hindlimb paralysis / MGI
- abnormal uterus morphology / MGI
- lung hemorrhage / MGI
- thick skin / MGI
- skin hyperplasia / MGI
- abnormal dermal layer morphology / MGI
- thick dermal layer / MGI
- increased body length / MGI
- decreased body length / MGI
- increased body weight / MGI
- decreased body weight / MGI
- increased body size / MGI
- decreased body size / MGI
- abnormal tail movements / MGI
- abnormal locomotor behavior / MGI
- hypoactivity / MGI
- abnormal gait / MGI
- abnormal motor coordination/balance / MGI
- abnormal osteoclast physiology / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal blood vessel morphology / MGI
- embryonic growth arrest / MGI
- lung inflammation / MGI
- hemorrhage / MGI
- intracranial hemorrhage / MGI
- increased litter size / MGI
- decreased litter size / MGI
- delayed sexual maturation / MGI
- respiratory distress / MGI
- abnormal coat/hair pigmentation / MGI
- premature death / MGI
- abnormal limb morphology / MGI
- abnormal digit morphology / MGI
- abnormal limb bone morphology / MGI
- abnormal fertility/fecundity / MGI
- no abnormal phenotype detected / MGI
- abnormal fibula morphology / MGI
- abnormal turbinate morphology / MGI
- decreased susceptibility to hepatic steatosis / MGI
- abnormal blood gas level / MGI
- delayed vaginal opening / MGI
- decreased circulating insulin level / MGI
- abnormal mechanical nociception / MGI
- decreased vertical activity / MGI
- abnormal dental pulp cavity morphology / MGI
- coarse hair / MGI
- increased growth rate / MGI
- increased insulin sensitivity / MGI
- abnormal bone mineralization / MGI
- increased circulating parathyroid hormone level / MGI
- decreased circulating alkaline phosphatase level / MGI
- arthritis / MGI
- abnormal bone healing / MGI
- no phenotypic analysis / MGI
- decreased skin tensile strength / MGI
- decreased tendon stiffness / MGI
- short femur / MGI
- decreased susceptibility to age related obesity / MGI
- aneurysm / MGI
- osteoarthritis / MGI
- abnormal long bone morphology / MGI
- abnormal compact bone morphology / MGI
- abnormal forelimb zeugopod morphology / MGI
- increased hepatocyte proliferation / MGI
- abnormal hormone level / MGI
- increased lean body mass / MGI
- decreased thermal nociceptive threshold / MGI
- decreased bone mass / MGI
- aortic dissection / MGI
- abnormal chest morphology / MGI
- abnormal pubis morphology / MGI
- abnormal ischium morphology / MGI
- abnormal pelvic girdle bone morphology / MGI
- thin ribs / MGI
- rib fractures / MGI
- decreased length of long bones / MGI
- abnormal vertebral column morphology / MGI
- short vertebral body / MGI
- increased susceptibility to age-related hearing loss / MGI
- abnormal osteoblast morphology / MGI
- increased osteoblast cell number / MGI
- decreased bone strength / MGI
- increased bone resorption / MGI
- abnormal osteoblast physiology / MGI
- liver hyperplasia / MGI
- decreased susceptibility to injury / MGI
- ocular hypertension / MGI
- improved glucose tolerance / MGI
- abnormal humerus morphology / MGI
- abnormal enzyme/coenzyme level / MGI
- abnormal myocardium layer morphology / MGI
- homeostasis/metabolism phenotype / MGI
- hearing/vestibular/ear phenotype / MGI
- digestive/alimentary phenotype / MGI
- reproductive system phenotype / MGI
- skeleton phenotype / MGI
- vision/eye phenotype / MGI
- decreased percent body fat/body weight / MGI
- abnormal skeleton morphology / MGI
- decreased circulating glucose level / MGI
- decreased ventricle muscle contractility / MGI
- decreased susceptibility to diet-induced obesity / MGI
- spinal hemorrhage / MGI
- abnormal heart septum morphology / MGI
- impaired hearing / MGI
- decreased diameter of femur / MGI
- abnormal myometrium morphology / MGI
- abnormal osteoblast differentiation / MGI
- abnormal cutaneous collagen fibril morphology / MGI
- abnormal osteocyte morphology / MGI
- fused carpal bones / MGI
- delayed female fertility / MGI
- small pancreatic islets / MGI
- decreased trabecular bone thickness / MGI
- abnormal endoplasmic reticulum morphology / MGI
- abnormal aorta elastic tissue morphology / MGI
- abnormal aorta tunica adventitia morphology / MGI
- decreased total body fat amount / MGI
- abnormal thoracic cage shape / MGI
- decreased bone mineral content / MGI
- abnormal heart electrocardiography waveform feature / MGI
- myocardial hypertrophy / MGI
- increased QRS amplitude / MGI
- abnormal bone trabecula morphology / MGI
- decreased bone trabecula number / MGI
- decreased bone volume / MGI
- decreased trabecular bone volume / MGI
- pulmonary alveolar hemorrhage / MGI
- abnormal compact bone lamellar structure / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- abnormal bone collagen fibril morphology / MGI
- abnormal tendon collagen fibril morphology / MGI
- decreased neuronal stem cell self-renewal / MGI
- thin body / MGI
- abnormal extracellular matrix morphology / MGI
- osteophytes / MGI
- increased bone trabecular spacing / MGI
- decreased bone trabecular spacing / MGI
- decreased bone ossification / MGI
- decreased bone mineralization / MGI
- decreased collagen level / MGI
- broad face / MGI
- thick neurocranium / MGI
- thin neurocranium / MGI
- increased osteoblast apoptosis / MGI
- abnormal dentin mineralization / MGI
- increased osteocyte apoptosis / MGI
- abnormal osteocyte lacuna morphology / MGI
- joint contracture / MGI
- atlanto-occipital joint dislocation / MGI
- abnormal olecranon morphology / MGI
- abnormal ear pigmentation / MGI
- decreased circulating LDL cholesterol level / MGI
- decreased hematocrit / MGI
- increased leukocyte cell number / MGI
- decreased neutrophil cell number / MGI
- extramedullary hematopoiesis / MGI
- abnormal erythropoiesis / MGI
- abnormal myocardial fiber morphology / MGI
- abnormal cell death / MGI
- increased granulocyte number / MGI
- increased cell proliferation / MGI
- alopecia / MGI
- short snout / MGI
- abnormal digestive system morphology / MGI
- gastrointestinal hemorrhage / MGI
- increased rib number / MGI
- abnormal pulmonary artery morphology / MGI
- rectal prolapse / MGI
- abnormal renal/urinary system morphology / MGI
- abnormal mammary gland development / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- dystrophic muscle / MGI
- absent notochord / MGI
- abnormal retinal photoreceptor morphology / MGI
- abnormal neuromuscular synapse morphology / MGI
- pigmentation phenotype / MGI
- increased body weight / MGI
- decreased body weight / MGI
- decreased body size / MGI
- retinal degeneration / MGI
- disorganized retinal layers / MGI
- abnormal optic nerve morphology / MGI
- decreased anxiety-related response / MGI
- circling / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- abnormal eating behavior / MGI
- limb grasping / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- increased circulating HDL cholesterol level / MGI
- hyperglycemia / MGI
- anemia / MGI
- abnormal blood vessel morphology / MGI
- abnormal mesoderm development / MGI
- abnormal somite development / MGI
- decreased trophoblast giant cell number / MGI
- postnatal growth retardation / MGI
- impaired wound healing / MGI
- abnormal humoral immune response / MGI
- arrested B cell differentiation / MGI
- arrested T cell differentiation / MGI
- increased inflammatory response / MGI
- reduced fertility / MGI
- reduced female fertility / MGI
- male infertility / MGI
- decreased litter size / MGI
- respiratory distress / MGI
- abnormal pain threshold / MGI
- increased thermal nociceptive threshold / MGI
- abnormal coat/hair pigmentation / MGI
- abnormal glucose homeostasis / MGI
- increased circulating insulin level / MGI
- premature death / MGI
- abnormal tail morphology / MGI
- abnormal kidney morphology / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal seminiferous tubule morphology / MGI
- small lymph nodes / MGI
- abnormal spleen white pulp morphology / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal megakaryocyte progenitor cell morphology / MGI
- abnormal proerythroblast morphology / MGI
- abnormal megakaryocyte morphology / MGI
- increased mean corpuscular volume / MGI
- decreased mean corpuscular volume / MGI
- increased mean platelet volume / MGI
- hepatic steatosis / MGI
- abnormal epididymis morphology / MGI
- vestigial tail / MGI
- reticulocytosis / MGI
- abnormal keratinocyte differentiation / MGI
- decreased circulating corticosterone level / MGI
- asthenozoospermia / MGI
- oligozoospermia / MGI
- abnormal renal tubule morphology / MGI
- decreased circulating insulin level / MGI
- abnormal chemical nociception / MGI
- dilated heart left ventricle / MGI
- decreased vertical activity / MGI
- abnormal notochord morphology / MGI
- abnormal ocular fundus morphology / MGI
- albuminuria / MGI
- decreased hemoglobin content / MGI
- decreased erythrocyte cell number / MGI
- no phenotypic analysis / MGI
- vertebral transformation / MGI
- abnormal lumbar vertebrae morphology / MGI
- abnormal skeletal muscle fiber morphology / MGI
- absent allantois / MGI
- hypospadia / MGI
- anal atresia / MGI
- increased erythroid progenitor cell number / MGI
- abnormal embryonic hematopoiesis / MGI
- kinked neural tube / MGI
- epididymal inflammation / MGI
- nervous system phenotype / MGI
- abnormal nervous system morphology / MGI
- kidney cysts / MGI
- pallor / MGI
- abnormal neural tube closure / MGI
- abnormal retinal inner nuclear layer morphology / MGI
- vascular smooth muscle hypoplasia / MGI
- skeletal muscle necrosis / MGI
- abnormal defecation / MGI
- abnormal heart left ventricle morphology / MGI
- abnormal circulating lipid level / MGI
- abnormal hormone level / MGI
- increased lean body mass / MGI
- abnormal rod electrophysiology / MGI
- abnormal cone electrophysiology / MGI
- caudal body truncation / MGI
- abnormal vitelline vascular remodeling / MGI
- abnormal sarcomere morphology / MGI
- increased compact bone thickness / MGI
- transmission ratio distortion / MGI
- abnormal basement membrane morphology / MGI
- short frontal bone / MGI
- short nasal bone / MGI
- increased incidence of tumors by chemical induction / MGI
- caudal vertebral transformation / MGI
- cervical vertebral transformation / MGI
- lumbar vertebral transformation / MGI
- thoracic vertebral transformation / MGI
- cervical vertebral fusion / MGI
- absent caudal vertebrae / MGI
- small sacral vertebrae / MGI
- abnormal vertebral column morphology / MGI
- notochord degeneration / MGI
- truncated notochord / MGI
- abnormal platelet morphology / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- increased hematopoietic stem cell number / MGI
- decreased testis weight / MGI
- increased energy expenditure / MGI
- decreased adiponectin level / MGI
- decreased epididymis weight / MGI
- abnormal epididymis epithelium morphology / MGI
- skin inflammation / MGI
- decreased B-1 B cell number / MGI
- increased neuronal precursor cell number / MGI
- increased osteoblast cell number / MGI
- decreased lymphocyte cell number / MGI
- decreased cardiac muscle contractility / MGI
- cachexia / MGI
- increased susceptibility to injury / MGI
- decreased circulating cholesterol level / MGI
- abnormal retinal pigment epithelium morphology / MGI
- abnormal rostral-caudal axis patterning / MGI
- glomerulosclerosis / MGI
- increased oxygen consumption / MGI
- impaired glucose tolerance / MGI
- spina bifida occulta / MGI
- decreased triglyceride level / MGI
- abnormal renal glomerulus morphology / MGI
- insulin resistance / MGI
- muscle phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- endocrine/exocrine gland phenotype / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- reproductive system phenotype / MGI
- skeleton phenotype / MGI
- hematopoietic system phenotype / MGI
- increased circulating thyroxine level / MGI
- increased circulating triiodothyronine level / MGI
- abnormal skeleton morphology / MGI
- abnormal body temperature / MGI
- choroidal neovascularization / MGI
- abnormal eye electrophysiology / MGI
- decreased circulating glucose level / MGI
- increased mean corpuscular hemoglobin / MGI
- decreased mean corpuscular hemoglobin / MGI
- decreased angiogenesis / MGI
- increased bone mass / MGI
- abnormal cell physiology / MGI
- increased susceptibility to diet-induced obesity / MGI
- decreased susceptibility to diet-induced obesity / MGI
- decreased circulating leptin level / MGI
- increased circulating leptin level / MGI
- increased mitochondrial fission / MGI
- increased apoptosis / MGI
- abnormal tail development / MGI
- abnormal spermatid morphology / MGI
- intestine polyps / MGI
- abnormal paraxial mesoderm morphology / MGI
- abnormal podocyte slit diaphragm morphology / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- abnormal granulocyte differentiation / MGI
- abnormal monocyte differentiation / MGI
- podocyte foot process effacement / MGI
- increased germinal center B cell number / MGI
- decreased B-2 B cell number / MGI
- decreased mature B cell number / MGI
- increased megakaryocyte cell number / MGI
- abnormal bone ossification / MGI
- retinal photoreceptor degeneration / MGI
- abnormal medium spiny neuron morphology / MGI
- retinal outer nuclear layer degeneration / MGI
- increased circulating tumor necrosis factor level / MGI
- increased circulating interleukin-1 alpha level / MGI
- increased circulating interleukin-1 beta level / MGI
- increased interleukin-17 secretion / MGI
- decreased survivor rate / MGI
- increased B cell apoptosis / MGI
- increased liver iron level / MGI
- increased spleen iron level / MGI
- increased circulating iron level / MGI
- lipofuscinosis / MGI
- abnormal physiological response to xenobiotic / MGI
- decreased erythroid progenitor cell number / MGI
- anal stenosis / MGI
- hairpin sperm flagellum / MGI
- increased abdominal fat pad weight / MGI
- increased trophoblast giant cell number / MGI
- centrally nucleated skeletal muscle fibers / MGI
- skeletal muscle endomysial fibrosis / MGI
- abnormal synaptonemal complex / MGI
- abnormal mammary gland duct morphology / MGI
- decreased thymocyte apoptosis / MGI
- enlarged popliteal lymph nodes / MGI
- decreased birth body size / MGI
- impaired somite development / MGI
- increased total body fat amount / MGI
- abnormal placenta physiology / MGI
- abnormal retinal blood vessel morphology / MGI
- decreased mammary gland epithelial cell proliferation / MGI
- decreased tumor latency / MGI
- altered tumor pathology / MGI
- mortality/aging / MGI
- integument phenotype / MGI
- increased bone volume / MGI
- abnormal double-strand DNA break repair / MGI
- neonatal lethality, complete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- abnormal anterior visceral endoderm cell migration / MGI
- increased circulating erythropoietin level / MGI
- renal tubule atrophy / MGI
- lethality, complete penetrance / MGI
- increased mitochondria number / MGI
- rectal atresia / MGI
- rectourethral fistula / MGI
- increased hematopoietic stem cell proliferation / MGI
- increased food intake / MGI
- impaired mammary gland growth during pregnancy / MGI
- decreased paraxial mesoderm size / MGI
- abnormal skeletal muscle regeneration / MGI
- testis degeneration / MGI
- preputial gland inflammation / MGI
- nervous system inclusion bodies / MGI
- decreased fatty acid beta-oxidation / MGI
- epididymis hypertrophy / MGI
- spermatocele / MGI
- epididymis fibrosis / MGI
- increased epididymal cell proliferation / MGI
- increased epididymal epithelium cell proliferation / MGI
- increased heart iron level / MGI
- increased intestinal iron level / MGI