- decreased bone mineral density / IMPC
- abnormal vertebrae morphology / IMPC
- decreased hematocrit / IMPC
- increased neutrophil cell number / IMPC
- decreased leukocyte cell number / IMPC
- abnormal head morphology / IMPC
- abnormal cranium morphology / IMPC
- abnormal snout morphology / IMPC
- abnormal radius morphology / IMPC
- abnormal tibia morphology / IMPC
- abnormal femur morphology / IMPC
- decreased body length / IMPC
- abnormal eyelid morphology / IMPC
- decreased caudal vertebrae number / IMPC
- abnormal hair growth / IMPC
- decreased heart weight / IMPC
- decreased hemoglobin content / IMPC
- decreased erythrocyte cell number / IMPC
- abnormal joint morphology / IMPC
- thrombocytopenia / IMPC
- abnormal bone structure / IMPC
- increased lean body mass / IMPC
- decreased lean body mass / IMPC
- abnormal vertebral arch morphology / IMPC
- increased T cell number / IMPC
- decreased B cell number / IMPC
- abnormal ulna morphology / IMPC
- abnormal zygomatic bone morphology / IMPC
- abnormal humerus morphology / IMPC
- abnormal clavicle morphology / IMPC
- increased mean corpuscular hemoglobin / IMPC
- increased mean corpuscular hemoglobin concentration / IMPC
- absent pinna reflex / IMPC
- decreased NK T cell number / IMPC
- decreased NK cell number / IMPC
- increased CD4-positive, alpha beta T cell number / IMPC
- increased CD8-positive, alpha-beta T cell number / IMPC
- decreased CD8-positive, alpha-beta T cell number / IMPC
- decreased follicular B cell number / IMPC
- decreased B-2 B cell number / IMPC
- decreased mature B cell number / IMPC
- decreased immature B cell number / IMPC
- increased plasmacytoid dendritic cell number / IMPC
- decreased mean platelet volume / IMPC
- decreased transitional stage T1 B cell number / IMPC
- decreased total body fat amount / IMPC
- decreased grip strength / IMPC
- decreased red blood cell distribution width / IMPC
- abnormal thoracic cage shape / IMPC
- decreased bone mineral content / IMPC
- increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
- increased effector memory CD8-positive, alpha-beta T cell number / IMPC
- decreased food intake / IMPC
- increased or absent threshold for auditory brainstem response / IMPC
- increased alpha-beta T cell number / IMPC
- decreased KLRG1-positive NK cell number / IMPC
- decreased Ly6C low monocyte number / IMPC
- decreased memory-marker gamma-delta T cell number / IMPC
- decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
- increased CD8-positive, naive alpha-beta T cell number / IMPC
- decreased CD11b-high dendritic cell number / IMPC
- increased T-helper cell number / IMPC
- decreased effector memory T-helper cell number / IMPC
C57BL/6N-Duoxa2tm1b(KOMP)Wtsi/WtsiCnrm
Status | Available to order |
EMMA ID | EM:13391 |
International strain name | C57BL/6N-Duoxa2tm1b(KOMP)Wtsi/WtsiCnrm |
Alternative name | EPD0899_5_A06 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Duoxa2tm1b(KOMP)Wtsi, |
Gene/Transgene symbol | Duoxa2 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from KOMP ES clone EPD0899_5_A06. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele using a cell permeable HTN-Cre as described in doi:10.1007/s11248-013-9764-x. Click here for more information on KOMP final vectors. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial thyroid dyshormonogenesis / Orphanet_95716
IMPC phenotypes (allele matching)
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