B6Brd;B6N-Tyrc-Brd-Slc16a2tm1c(KOMP)Wtsi/WtsiCnrm

Status

Available to order

EMMA IDEM:13413
Citation informationRRID:IMSR_EM:13413 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6Brd;B6N-Tyrc-Brd-Slc16a2tm1c(KOMP)Wtsi/WtsiCnrm
Alternative nameEPD0109_3_E07
Strain typeTargeted Mutant Strains : Targeted Conditional
Allele/Transgene symbolSlc16a2tm1c(KOMP)Wtsi
Gene/Transgene symbolSlc16a2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis line originates from KOMP ES clone EPD0109_3_E07, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased circulating fructosamine level / IMPC
  • hyperplasia / IMPC
  • increased heart weight / IMPC
  • extramedullary hemopoiesis / IMPC
  • increased circulating magnesium level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased circulating calcium level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • decreased circulating creatinine level / IMPC
  • increased circulating amylase level / IMPC
MGI phenotypes (gene matching)
  • decreased circulating LDL cholesterol level / MGI
  • decreased circulating HDL cholesterol level / MGI
  • increased circulating alkaline phosphatase level / MGI
  • nervous system phenotype / MGI
  • decreased circulating cholesterol level / MGI
  • abnormal circulating hormone level / MGI
  • abnormal thyroxine level / MGI
  • abnormal triiodothyronine level / MGI
  • increased triiodothyronine level / MGI
  • decreased circulating thyroxine level / MGI
  • increased circulating triiodothyronine level / MGI
  • decreased circulating creatinine level / MGI
  • increased circulating amylase level / MGI
  • decreased circulating fructosamine level / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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