C57BL/6NCrl-Nacc1em1(IMPC)Hmgu/Ieg

Status

Available to order

EMMA IDEM:13447
Citation informationRRID:IMSR_EM:13447 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NCrl-Nacc1em1(IMPC)Hmgu/Ieg
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolNacc1em1(IMPC)Hmgu
Gene/Transgene symbolNacc1

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6N males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Severe neurodevelopmental disorder with feeding difficulties-stereotypic hand movement-bilateral cataract / Orphanet_500545
IMPC phenotypes (allele matching)
  • absent vibrissae / IMPC
  • abnormal retina morphology / IMPC
  • increased mean corpuscular volume / IMPC
  • short tibia / IMPC
  • abnormal auditory brainstem response / IMPC
  • impaired glucose tolerance / IMPC
  • polycystic kidney / IMPC
  • hydrometra / IMPC
  • decreased grip strength / IMPC
  • decreased bone mineral content / IMPC
  • decreased total retina thickness / IMPC
IMPC phenotypes (gene matching)
  • hydrometra / IMPC
  • decreased total retina thickness / IMPC
  • abnormal retina morphology / IMPC
  • impaired glucose tolerance / IMPC
  • increased mean corpuscular volume / IMPC
  • decreased bone mineral content / IMPC
  • polycystic kidney / IMPC
  • absent vibrissae / IMPC
  • abnormal auditory brainstem response / IMPC
  • short tibia / IMPC
  • decreased grip strength / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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