C57BL/6N-Slc29a3em1(IMPC)Wtsi/WtsiCnrm

Status

Available to order

EMMA IDEM:13448
Citation informationRRID:IMSR_EM:13448 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Slc29a3em1(IMPC)Wtsi/WtsiCnrm
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolSlc29a3em1(IMPC)Wtsi
Gene/Transgene symbolSlc29a3

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • decreased circulating LDL cholesterol level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • decreased hematocrit / IMPC
  • increased leukocyte cell number / IMPC
  • increased mean platelet volume / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased circulating chloride level / IMPC
  • thrombocytopenia / IMPC
  • increased lean body mass / IMPC
  • decreased circulating iron level / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased circulating bilirubin level / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating glucose level / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • decreased circulating total protein level / IMPC
  • increased circulating sodium level / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • increased circulating amylase level / IMPC
  • decreased total body fat amount / IMPC
  • increased red blood cell distribution width / IMPC
IMPC phenotypes (gene matching)
  • abnormal liver morphology / IMPC
  • increased lean body mass / IMPC
  • small uterus / IMPC
  • enlarged liver / IMPC
  • abnormal stomach morphology / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • hyperplasia / IMPC
  • decreased erythrocyte cell number / IMPC
  • abnormal lymph node morphology / IMPC
  • increased spleen weight / IMPC
  • enlarged spleen / IMPC
  • enlarged lymph nodes / IMPC
  • increased circulating chloride level / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • abnormal uterus morphology / IMPC
  • enlarged duodenum / IMPC
  • decreased circulating triglyceride level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • small kidney / IMPC
  • prolonged RR interval / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased red blood cell distribution width / IMPC
  • increased startle reflex / IMPC
  • enlarged ileum / IMPC
  • abnormal skin morphology / IMPC
  • abnormal kidney morphology / IMPC
  • increased circulating alanine transaminase level / IMPC
  • abnormal thymus morphology / IMPC
  • abnormal cecum morphology / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • fibrosis / IMPC
  • atrophy / IMPC
  • abnormal brain morphology / IMPC
  • decreased total body fat amount / IMPC
  • abnormal spleen morphology / IMPC
  • increased circulating sodium level / IMPC
  • small seminal vesicle / IMPC
  • abnormal lung morphology / IMPC
  • distended jejunum / IMPC
  • increased circulating amylase level / IMPC
  • decreased circulating iron level / IMPC
  • decreased circulating total protein level / IMPC
  • increased circulating bilirubin level / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • decreased hemoglobin content / IMPC
  • decreased circulating LDL cholesterol level / IMPC
  • thrombocytopenia / IMPC
  • enlarged cecum / IMPC
  • abnormal caudal vertebrae morphology / IMPC
  • decreased hematocrit / IMPC
  • increased mean platelet volume / IMPC
  • decreased heart rate / IMPC
  • decreased circulating glucose level / IMPC
  • increased leukocyte cell number / IMPC
  • small thymus / IMPC
  • increased liver weight / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased body length / IMPC
  • abnormal colon morphology / IMPC
MGI phenotypes (gene matching)
  • extramedullary hematopoiesis / MGI
  • enlarged spleen / MGI
  • enlarged lymph nodes / MGI
  • premature death / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal macrophage morphology / MGI
  • abnormal macrophage physiology / MGI
  • abnormal lysosome physiology / MGI
  • immune system phenotype / MGI
  • increased macrophage cell number / MGI
  • increased histiocytic sarcoma incidence / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • myeloid hyperplasia / MGI
  • increased macrophage apoptosis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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