- abnormal motor coordination/balance / IMPC
- decreased mean platelet volume / IMPC
- preweaning lethality, complete penetrance / IMPC
- abnormal retina vasculature morphology / IMPC
- increased total body fat amount / IMPC
- abnormal lens morphology / IMPC
- abnormal retina morphology / IMPC
- increased startle reflex / IMPC
- abnormal retina blood vessel morphology / IMPC
- increased NK cell number / IMPC
C57BL/6N-Jmjd6tm1c(EUCOMM)Wtsi/IegBiat
Status | Available to order |
EMMA ID | EM:13459 |
Citation information | RRID:IMSR_EM:13459 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6N-Jmjd6tm1c(EUCOMM)Wtsi/IegBiat |
Alternative name | C57BL/6N-Jmjd6tm1c(EUCOMM)Wtsi/IegBiat |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Jmjd6tm1c(EUCOMM)Wtsi |
Gene/Transgene symbol | Jmjd6 |
Information from provider
Provider | Maik Dahlhoff |
Provider affiliation | Department of Biomedical Sciences, University of Veterinary Medicine |
Genetic information | This line originates from EMMA strain EM:04584, C57BL/6N-Jmjd6tm1a(EUCOMM)Wtsi/Ieg (EUCOMM ES clone EPD0158_3_A11), after breeding with a flp recombinase-deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the relevant page at the IMPC portal (https://www.mousephenotype.org/data/genes/MGI:1858910#order). |
Phenotypic information | Homozygous:No homozygous mice have been producedHeterozygous:No data available, no phenotype expected |
Breeding history | 1 backcross generation to C57BL/6N after flp-deleter breeding. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | not known |
Immunocompromised | no |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- decreased hematocrit / MGI
- abnormal erythropoiesis / MGI
- double outlet right ventricle / MGI
- abnormal intestine morphology / MGI
- abnormal pulmonary artery morphology / MGI
- abnormal kidney development / MGI
- liver hypoplasia / MGI
- abnormal thymus development / MGI
- small thymus / MGI
- abnormal brain development / MGI
- exencephaly / MGI
- abnormal lung development / MGI
- anophthalmia / MGI
- cyanosis / MGI
- abnormal apoptosis / MGI
- skin edema / MGI
- impaired macrophage phagocytosis / MGI
- thymus hypoplasia / MGI
- respiratory failure / MGI
- abnormal respiratory system morphology / MGI
- decreased hemoglobin content / MGI
- no phenotypic analysis / MGI
- pallor / MGI
- impaired macrophage chemotaxis / MGI
- thin myocardium compact layer / MGI
- decreased fetal size / MGI
- fetal growth retardation / MGI
- abnormal heart ventricle morphology / MGI
- cellular phenotype / MGI
- increased nucleated erythrocyte cell number / MGI
- abnormal blood homeostasis / MGI
- cleft secondary palate / MGI
- ventricular septal defect / MGI
- myocardial trabeculae hypoplasia / MGI
- abnormal macrophage activation involved in immune response / MGI
- neonatal lethality, complete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- abnormal head shape / MGI
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