C57BL/6NCrl-Mettl5em1(IMPC)Hmgu/Ieg
Status | Available to order |
EMMA ID | EM:13474 |
International strain name | C57BL/6NCrl-Mettl5em1(IMPC)Hmgu/Ieg |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Mettl5em1(IMPC)Hmgu |
Gene/Transgene symbol | Mettl5 |
Information from provider
Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References |
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Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive primary microcephaly / Orphanet_2512
Literature references
- The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.;Ignatova Valentina V, Stolz Paul, Kaiser Steffen, Gustafsson Tobias H, Lastres Palma Rico, Sanz-Moreno Adrián, Cho Yi-Li, Amarie Oana V, Aguilar-Pimentel Antonio, Klein-Rodewald Tanja, Calzada-Wack Julia, Becker Lore, Marschall Susan, Kraiger Markus, Garrett Lillian, Seisenberger Claudia, Hölter Sabine M, Borland Kayla, Van De Logt Erik, Jansen Pascal W T C, Baltissen Marijke P, Valenta Magdalena, Vermeulen Michiel, Wurst Wolfgang, Gailus-Durner Valerie, Fuchs Helmut, Hrabe de Angelis Martin, Rando Oliver J, Kellner Stefanie M, Bultmann Sebastian, Schneider Robert, ;2020;Genes & development;34;715-729; 32217665
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