C57BL/6NCrl-Tanc2^{em1(IMPC)Hmgu}/Ieg

Status	Available to order
EMMA ID	EM:13497
Citation information	RRID:IMSR_EM:13497 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NCrl-Tanc2^{em1(IMPC)Hmgu}/Ieg
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Tanc2^{em1(IMPC)Hmgu}
Gene/Transgene symbol	Tanc2

Information from provider

Provider	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliation	Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.;Garrett Lillian, Da Silva-Buttkus Patricia, Rathkolb Birgit, Gerlini Raffaele, Becker Lore, Sanz-Moreno Adrian, Seisenberger Claudia, Zimprich Annemarie, Aguilar-Pimentel Antonio, Amarie Oana V, Cho Yi-Li, Kraiger Markus, Spielmann Nadine, Calzada-Wack Julia, Marschall Susan, Busch Dirk, Schmitt-Weber Carsten, Wolf Eckhard, Wurst Wolfgang, Fuchs Helmut, Gailus-Durner Valerie, Hölter Sabine M, Hrabě de Angelis Martin, ;2022;Disease models & mechanisms;15;; 34964047

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archiving	heterozygous C57BL/6N males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Non-specific syndromic intellectual disability / Orphanet_528084

IMPC phenotypes (allele matching)

abnormal locomotor behavior / IMPC
hyperactivity / IMPC
increased exploration in new environment / IMPC
increased circulating phosphate level / IMPC
short tibia / IMPC
increased circulating alkaline phosphatase level / IMPC
abnormal bone structure / IMPC
abnormal behavior / IMPC
impaired glucose tolerance / IMPC
decreased prepulse inhibition / IMPC
increased grip strength / IMPC
decreased respiratory quotient / IMPC
decreased thigmotaxis / IMPC

IMPC phenotypes (gene matching)

hyperactivity / IMPC
increased grip strength / IMPC
impaired glucose tolerance / IMPC
abnormal locomotor behavior / IMPC
decreased thigmotaxis / IMPC
increased circulating phosphate level / IMPC
decreased prepulse inhibition / IMPC
increased exploration in new environment / IMPC
abnormal behavior / IMPC
decreased respiratory quotient / IMPC
abnormal bone structure / IMPC
short tibia / IMPC
increased circulating alkaline phosphatase level / IMPC

Literature references

Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.;Garrett Lillian, Da Silva-Buttkus Patricia, Rathkolb Birgit, Gerlini Raffaele, Becker Lore, Sanz-Moreno Adrian, Seisenberger Claudia, Zimprich Annemarie, Aguilar-Pimentel Antonio, Amarie Oana V, Cho Yi-Li, Kraiger Markus, Spielmann Nadine, Calzada-Wack Julia, Marschall Susan, Busch Dirk, Schmitt-Weber Carsten, Wolf Eckhard, Wurst Wolfgang, Fuchs Helmut, Gailus-Durner Valerie, Hölter Sabine M, Hrabě de Angelis Martin, ;2022;Disease models & mechanisms;15;; 34964047

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6NCrl-Tanc2em1(IMPC)Hmgu/Ieg