C57BL/6NCrl-Tnksem1(IMPC)Hmgu/Ieg

Status

Available to order

EMMA IDEM:13515
Citation informationRRID:IMSR_EM:13515 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NCrl-Tnksem1(IMPC)Hmgu/Ieg
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolTnksem1(IMPC)Hmgu
Gene/Transgene symbolTnks

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6N males

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased bone mineral density / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • abnormal retina morphology / IMPC
  • abnormal gait / IMPC
  • hydrocephaly / IMPC
  • increased mean corpuscular volume / IMPC
  • increased mean platelet volume / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased vertical activity / IMPC
  • increased heart weight / IMPC
  • decreased erythrocyte cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • thrombocytopenia / IMPC
  • increased lean body mass / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased circulating bilirubin level / IMPC
  • decreased circulating glucose level / IMPC
  • decreased total body fat amount / IMPC
  • decreased grip strength / IMPC
  • increased red blood cell distribution width / IMPC
  • decreased bone mineral content / IMPC
  • decreased total retina thickness / IMPC
  • increased fasting circulating glucose level / IMPC
IMPC phenotypes (gene matching)
  • decreased total retina thickness / IMPC
  • decreased bone mineral content / IMPC
  • increased circulating bilirubin level / IMPC
  • increased red blood cell distribution width / IMPC
  • decreased total body fat amount / IMPC
  • hydrocephaly / IMPC
  • increased fasting circulating glucose level / IMPC
  • abnormal gait / IMPC
  • decreased bone mineral density / IMPC
  • decreased grip strength / IMPC
  • decreased erythrocyte cell number / IMPC
  • increased lean body mass / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased mean corpuscular volume / IMPC
  • increased mean platelet volume / IMPC
  • thrombocytopenia / IMPC
  • decreased circulating glucose level / IMPC
  • abnormal retina morphology / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • decreased circulating triglyceride level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased heart weight / IMPC
  • decreased vertical activity / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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