C57BL/6N-Chd2em1.1(IMPC)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:13525
Citation informationRRID:IMSR_EM:13525 

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International strain nameC57BL/6N-Chd2em1.1(IMPC)Wtsi/WtsiH
Alternative nameChd2tm1.2(IMPC)Wtsi
Strain typeEndonuclease-mediated
Allele/Transgene symbolChd2em1.1(IMPC)Wtsi
Gene/Transgene symbolChd2

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationChd2tm1.2(IMPC)Wtsi. KO first WT function activiated by cre excision of cassette. Post flp excision. Note: ES cells were generated using the CRISPR/Cas9 technology. The details of the applied experimental procedures involving CRISPR/Cas9 technology are not available.
Phenotypic informationHomozygous:
data not available

Heterozygous:
data not available
Breeding historyChimeras crossed with flp on C57BL/6N and crossed with C57BL/6N, then intercrossed
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • short tibia / IMPC
  • abnormal bone structure / IMPC
  • decreased prepulse inhibition / IMPC
  • decreased mean platelet volume / IMPC
  • increased grip strength / IMPC
  • decreased body length / IMPC
  • increased circulating alanine transaminase level / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • fibro-osseous lesion / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • decreased bone mineral content / IMPC
  • hyperplasia / IMPC
  • abnormal sinus arrhythmia / IMPC
  • decreased bone mineral density / IMPC

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Practical information

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