C57BL/6N-Adnp2em1Wtsi/WtsiH

Status

Available to order

EMMA IDEM:13528
Citation informationRRID:IMSR_EM:13528 

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International strain nameC57BL/6N-Adnp2em1Wtsi/WtsiH
Alternative nameAdnptm1.1Wtsi
Strain typeEndonuclease-mediated
Allele/Transgene symbolAdnp2em1Wtsi
Gene/Transgene symbolAdnp2

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationAdnp2a_GFP_H2b. KO first WT function activated by cre excision of cassettte. Pre flp excision of selectable marker. Note: ES cells were generated using the CRISPR/Cas9 technology. The details of the applied experimental procedures involving CRISPR/Cas9 technology are not available.
Phenotypic informationHomozygous:
data not available

Heterozygous:
data not available
Breeding historyChimeras crossed with C57BL/6N then crossed with C57BL/6N
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased circulating serum albumin level / IMPC
  • decreased prepulse inhibition / IMPC
  • small spleen / IMPC
  • hypoplasia / IMPC
  • increased grip strength / IMPC
  • abnormal ovary morphology / IMPC
  • neoplasia / IMPC
  • abnormal liver morphology / IMPC
  • abnormal uterus morphology / IMPC
  • abnormal thymus morphology / IMPC
  • abnormal bone structure / IMPC
  • short tibia / IMPC
  • small kidney / IMPC
  • decreased body length / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • absent adrenal gland / IMPC
  • small adrenal glands / IMPC
  • abnormal sternum morphology / IMPC
  • decreased bone mineral density / IMPC
  • hyperactivity / IMPC
  • abnormal lung morphology / IMPC
  • small uterus / IMPC
  • enlarged lymph nodes / IMPC
  • decreased exploration in new environment / IMPC
  • decreased circulating total protein level / IMPC
  • decreased bone mineral content / IMPC

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Availabilities

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Practical information

Genotyping protocol

Example health report
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