C57BL/6NCrl-Dmdem1(IMPC)Hmgu/Ieg

Status

Available to order

EMMA IDEM:13583
Citation informationRRID:IMSR_EM:13583 

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International strain nameC57BL/6NCrl-Dmdem1(IMPC)Hmgu/Ieg
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolDmdem1(IMPC)Hmgu
Gene/Transgene symbolDmd

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6N males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • decreased mean corpuscular volume / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased circulating serum albumin level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal bone structure / IMPC
  • increased lean body mass / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • thrombocytosis / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • increased circulating total protein level / IMPC
  • decreased total body fat amount / IMPC
  • decreased grip strength / IMPC
  • increased red blood cell distribution width / IMPC
  • decreased bone mineral content / IMPC
IMPC phenotypes (gene matching)
  • increased circulating alanine transaminase level / IMPC
  • increased lean body mass / IMPC
  • increased circulating serum albumin level / IMPC
  • decreased total body fat amount / IMPC
  • decreased mean corpuscular volume / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • thrombocytosis / IMPC
  • decreased bone mineral content / IMPC
  • increased red blood cell distribution width / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased circulating total protein level / IMPC
  • abnormal bone structure / IMPC
  • decreased grip strength / IMPC
  • increased circulating alkaline phosphatase level / IMPC
MGI phenotypes (gene matching)
  • enlarged heart / MGI
  • abnormal myocardial fiber morphology / MGI
  • abnormal myogenesis / MGI
  • increased satellite cell number / MGI
  • abnormal muscle development / MGI
  • muscle weakness / MGI
  • muscle degeneration / MGI
  • myopathy / MGI
  • dystrophic muscle / MGI
  • abnormal skeletal muscle morphology / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • decreased body weight / MGI
  • increased body size / MGI
  • decreased body size / MGI
  • impaired coordination / MGI
  • abnormal grip strength / MGI
  • heart inflammation / MGI
  • myocarditis / MGI
  • reduced fertility / MGI
  • reduced female fertility / MGI
  • decreased litter size / MGI
  • abnormal muscle physiology / MGI
  • abnormal muscle morphology / MGI
  • abnormal cardiovascular system morphology / MGI
  • no abnormal phenotype detected / MGI
  • muscular atrophy / MGI
  • abnormal diaphragm morphology / MGI
  • abnormal intercostal muscle morphology / MGI
  • decreased susceptibility to viral infection / MGI
  • dystrophic cardiac calcinosis / MGI
  • impaired skeletal muscle contractility / MGI
  • thick ventricular wall / MGI
  • no phenotypic analysis / MGI
  • decreased aerobic running capacity / MGI
  • abnormal skeletal muscle fiber morphology / MGI
  • abnormal heart atrium morphology / MGI
  • calcified muscle / MGI
  • decreased cardiac output / MGI
  • nervous system phenotype / MGI
  • skeletal muscle necrosis / MGI
  • abnormal plasma membrane morphology / MGI
  • prolonged P wave / MGI
  • abnormal muscle fiber morphology / MGI
  • dilated sarcoplasmic reticulum / MGI
  • abnormal sarcolemma morphology / MGI
  • abnormal muscle tone / MGI
  • abnormal muscle electrophysiology / MGI
  • abnormal myocardial fiber physiology / MGI
  • myositis / MGI
  • increased susceptibility to noise-induced hearing loss / MGI
  • abnormal vertebral column morphology / MGI
  • increased skeletal muscle mass / MGI
  • decreased skeletal muscle mass / MGI
  • increased growth hormone level / MGI
  • decreased cardiac muscle contractility / MGI
  • cardiomyopathy / MGI
  • muscle phenotype / MGI
  • adipose tissue phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • cardiovascular system phenotype / MGI
  • abnormal Muller cell morphology / MGI
  • abnormal muscle contractility / MGI
  • myocardial necrosis / MGI
  • retinal ischemia / MGI
  • abnormal corticotroph morphology / MGI
  • increased somatotroph cell size / MGI
  • increased tumor necrosis factor secretion / MGI
  • increased interferon-gamma secretion / MGI
  • increased interleukin-12 secretion / MGI
  • increased interleukin-2 secretion / MGI
  • increased interleukin-4 secretion / MGI
  • increased interleukin-6 secretion / MGI
  • increased transforming growth factor level / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased skeletal muscle fiber size / MGI
  • increased skeletal muscle fiber diameter / MGI
  • decreased skeletal muscle fiber diameter / MGI
  • increased variability of skeletal muscle fiber size / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • increased skeletal muscle fiber number / MGI
  • decreased skeletal muscle fiber number / MGI
  • abnormal skeletal muscle satellite cell proliferation / MGI
  • skeletal muscle fiber degeneration / MGI
  • skeletal muscle fiber atrophy / MGI
  • skeletal muscle fiber necrosis / MGI
  • skeletal muscle degeneration / MGI
  • cardiac muscle degeneration / MGI
  • skeletal muscle atrophy / MGI
  • skeletal muscle fibrosis / MGI
  • skeletal muscle endomysial fibrosis / MGI
  • skeletal muscle hypertrophy / MGI
  • increased total body fat amount / MGI
  • decreased grip strength / MGI
  • increased circulating creatine kinase level / MGI
  • abnormal circulating pyruvate kinase level / MGI
  • increased quadriceps weight / MGI
  • decreased quadriceps weight / MGI
  • increased skeletal muscle weight / MGI
  • decreased skeletal muscle weight / MGI
  • anterior subcapsular cataracts / MGI
  • nuclear cataracts / MGI
  • prolonged QRS complex duration / MGI
  • decreased P wave amplitude / MGI
  • abnormal atrium myocardial trabeculae morphology / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • decreased cardiac stroke volume / MGI
  • abnormal auditory brainstem response waveform shape / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • impaired exercise endurance / MGI
  • abnormal skeletal muscle regeneration / MGI
  • increased creatine kinase activity / MGI
  • abnormal scalene muscle morphology / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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