- increased neutrophil cell number / IMPC
- abnormal heart morphology / IMPC
- enlarged heart / IMPC
- abnormal skin morphology / IMPC
- abnormal cholesterol homeostasis / IMPC
- increased circulating aspartate transaminase level / IMPC
- increased NK cell number / IMPC
- increased effector memory CD8-positive, alpha-beta T cell number / IMPC
C57BL/6NCrl-Tnfrsf1aem1(IMPC)Ccpcz/Ph
Status | Under development - register interest |
EMMA ID | EM:13591 |
Citation information | RRID:IMSR_EM:13591 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6NCrl-Tnfrsf1aem1(IMPC)Ccpcz/Ph |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Tnfrsf1aem1(IMPC)Ccpcz |
Gene/Transgene symbol | Tnfrsf1a |
Information from provider
Provider | Institute of Molecular Genetics |
Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Tumor necrosis factor receptor 1 associated periodic syndrome / Orphanet_32960
IMPC phenotypes (allele matching)
IMPC phenotypes (gene matching)
- abnormal skin morphology / IMPC
- increased large unstained cell number / IMPC
- increased grip strength / IMPC
- increased basophil cell number / IMPC
- increased neutrophil cell number / IMPC
- increased eosinophil cell number / IMPC
- increased NK cell number / IMPC
- abnormal cholesterol homeostasis / IMPC
- decreased circulating calcium level / IMPC
- increased lymphocyte cell number / IMPC
- increased effector memory CD8-positive, alpha-beta T cell number / IMPC
- increased circulating aspartate transaminase level / IMPC
- enlarged heart / IMPC
- increased leukocyte cell number / IMPC
- decreased monocyte cell number / IMPC
- abnormal heart morphology / IMPC
- decreased neutrophil cell number / IMPC
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- abnormal Peyer's patch morphology / MGI
- abnormal sleep pattern / MGI
- abnormal immune system physiology / MGI
- decreased IgG level / MGI
- liver inflammation / MGI
- lung inflammation / MGI
- decreased inflammatory response / MGI
- increased skin papilloma incidence / MGI
- decreased tumor incidence / MGI
- abnormal respiratory mechanics / MGI
- abnormal airway responsiveness / MGI
- abnormal lymph node B cell domain morphology / MGI
- abnormal spleen germinal center morphology / MGI
- abnormal Peyer's patch follicle morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- granulomatous inflammation / MGI
- impaired skin barrier function / MGI
- abnormal glutamate-mediated receptor currents / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- abnormal nervous system physiology / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- increased susceptibility to parasitic infection / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- decreased Peyer's patch number / MGI
- abnormal follicular dendritic cell morphology / MGI
- absent follicular dendritic cells / MGI
- decreased IgG1 level / MGI
- increased circulating tumor necrosis factor level / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-1 beta level / MGI
- increased interleukin-6 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal chemokine secretion / MGI
- decreased susceptibility to endotoxin shock / MGI
- increased susceptibility to endotoxin shock / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced cell death / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal neuron proliferation / MGI
- abnormal oval cell physiology / MGI
- tumor regression / MGI
- impaired adaptive thermogenesis / MGI
- decreased susceptibility to dopaminergic neuron neurotoxicity / MGI
- decreased microglial cell number / MGI
- impaired humoral immune response / MGI
- impaired central nervous system regeneration / MGI
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