MGI phenotypes (gene matching)
B6.FVB-Chl1em1Aoao Cntn6em1Aoao Cntn4em1Aoao/H
| Status | Available to order |
| EMMA ID | EM:13639 |
| Citation information | RRID:IMSR_EM:13639 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.FVB-Chl1em1Aoao Cntn6em1Aoao Cntn4em1Aoao/H |
| Alternative name | B6JFVBF1-3p del |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Chl1em1Aoao, Cntn6em1Aoao, Cntn4em1Aoao |
| Gene/Transgene symbol | Chl1, Cntn6, Cntn4 |
Information from provider
| Provider | Asami Oguro-Ando |
| Provider affiliation | University of Exeter Medical School, University of Exeter |
| Genetic information | A triple gene knock-out mouse model. CRISPR/Cas9 gene editing has been used to knock-out three genes on mouse chromosome 6 (orthologous human genes clustered on chromosome 3 region 3p26.3). The three genes are Cntn6, Cntn4 and Chl1. The following mutations were created: - deletion of 2bp and insertion of 69bp in exon 4 of Chl1 gene; - deletion of 9bp in exon 5 of Cntn4 gene; -deletion of 2bp in exon 3 of Cntn6 gene. |
| Phenotypic information | Homozygous:Under testingHeterozygous:Under testing |
| Breeding history | There have been more than 10 generations of backcrosses on the C57BL/6 background. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |