B6.FVB-Chl1em1Aoao Cntn6em1Aoao Cntn4em1Aoao/H
| Status | Available to order |
| EMMA ID | EM:13639 |
| International strain name | B6.FVB-Chl1em1Aoao Cntn6em1Aoao Cntn4em1Aoao/H |
| Alternative name | B6JFVBF1-3p del |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Cntn4em1 |
| Gene/Transgene symbol | Cntn4 |
Information from provider
| Provider | Asami Oguro-Ando |
| Provider affiliation | University of Exeter Medical School, University of Exeter |
| Genetic information | A triple gene knock-out mouse model. CRISPR/Cas9 gene editing has been used to knock-out three genes on mouse chromosome 6 (orthologous human genes clustered on chromosome 3 region 3p26.3). The three genes are Cntn6, Cntn4 and Chl1. The following mutations were created: - deletion of 2bp and insertion of 69bp in exon 4 of Chl1 gene; - deletion of 9bp in exon 5 of Cntn4 gene; -deletion of 2bp in exon 3 of Cntn6 gene. |
| Phenotypic information | Homozygous:Under testingHeterozygous:Under testing |
| Breeding history | There have been more than 10 generations of backcrosses on the C57BL/6 background. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |