C57BL/6N-Mettm1(MET*)Tcre/Cnrm
Status | Available to order |
EMMA ID | EM:13662 |
International strain name | C57BL/6N-Mettm1(MET*)Tcre/Cnrm |
Alternative name | hMETki |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Mettm1(MET*)Tcre, |
Gene/Transgene symbol | Met |
Information from provider
Provider | PAOLO COMOGLIO |
Provider affiliation | IFOM - Istituto FIRC di Oncologia Molecolare |
Additional owner | Tiziana Crepaldi, Ph.D., Department of Oncology, University of Turin, Candiolo Cancer Institute, Candiolo (Torino) ITALY |
Genetic information | hMETki mice harbour the "humanized" knock-in mutation of the wild-type human MET gene, which replaces the mouse Met gene. The coding region of exon 3 plus partial intron 3 was replaced with the mutant human MET CDS (NM_000245.4; 4173 bp). C57BL/6N ES cells were used for gene targeting. |
Phenotypic information | Homozygous:not knownHeterozygous:Mice heterozygous for the hMETki allele are viable and fertile |
Breeding history | The hMETki were bred with C57BL/6N to generate the heterozygous mice. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pediatric hepatocellular carcinoma / Orphanet_33402
- Papillary renal cell carcinoma / Orphanet_319298
- Osteofibrous dysplasia / Orphanet_488265
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
- Hereditary papillary renal cell carcinoma / Orphanet_47044
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