STOCK Plcg2tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:13679
Citation informationRRID:IMSR_EM:13679 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Plcg2tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0636_2_D02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolPlcg2tm1a(EUCOMM)Hmgu
Gene/Transgene symbolPlcg2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0636_2_D02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • PLCG2-associated antibody deficiency and immune dysregulation / Orphanet_300359
    • Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation / Orphanet_324530
IMPC phenotypes (gene matching)
  • increased T cell number / IMPC
  • hyperactivity / IMPC
  • decreased hemoglobin content / IMPC
  • abnormal glucose homeostasis / IMPC
  • thrombocytosis / IMPC
  • decreased hematocrit / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased IgG3 level / IMPC
  • decreased mature B cell number / IMPC
  • decreased circulating free fatty acids level / IMPC
  • increased IgM level / IMPC
  • increased IgG1 level / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased bone mineral density / IMPC
  • increased IgG2b level / IMPC
  • decreased erythrocyte cell number / IMPC
MGI phenotypes (gene matching)
  • abnormal trabecular bone morphology / MGI
  • abnormal foot pad morphology / MGI
  • spleen hyperplasia / MGI
  • dermatitis / MGI
  • internal hemorrhage / MGI
  • abnormal humoral immune response / MGI
  • arrested B cell differentiation / MGI
  • decreased IgM level / MGI
  • abnormal inflammatory response / MGI
  • abnormal lymphatic vessel morphology / MGI
  • premature death / MGI
  • abnormal B cell differentiation / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal B cell physiology / MGI
  • chronic inflammation / MGI
  • glomerulonephritis / MGI
  • increased pre-B cell number / MGI
  • decreased susceptibility to induced arthritis / MGI
  • osteoarthritis / MGI
  • decreased osteoclast cell number / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased B cell proliferation / MGI
  • increased B cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal dendritic cell morphology / MGI
  • decreased B-1a cell number / MGI
  • decreased follicular B cell number / MGI
  • increased pro-B cell number / MGI
  • decreased transitional stage B cell number / MGI
  • decreased B-2 B cell number / MGI
  • decreased mature B cell number / MGI
  • abnormal osteoclast differentiation / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • increased B cell apoptosis / MGI
  • increased trabecular bone thickness / MGI
  • decreased platelet aggregation / MGI
  • increased transitional stage T2 B cell number / MGI
  • abnormal dendritic cell chemotaxis / MGI
  • abnormal NK cell physiology / MGI
  • increased trabecular bone volume / MGI
  • chylous ascites / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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