C.Cg-Tg(IGHMdeltaV)6Corc/Cnrm
| Status | Available to order |
| EMMA ID | EM:01369 |
| International strain name | C.Cg-Tg(IGHMdeltaV)6Corc/Cnrm |
| Alternative name | delta-V mu 6 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(IGHMdeltaV)6Corc, |
| Gene/Transgene symbol | Tg(IGHMdeltaV)6Corc |
Information from provider
| Provider | Daniel Corcos |
| Provider affiliation | ER70 CNRS et Unite 125 Inserm |
| Genetic information | The delta-V mu construct encodes a human immunoglobulin mu heavy chain with a total deletion of the VDJ exon. |
| Phenotypic information | Expression of the delta-V mu construct in conventional B cells leads to a quasi-total allelic exclusion of endogenous immunoglobulin genes. As a consequence, B cells express a truncated B-cell receptor devoid of antigen binding domain. The delta-V mu protein allows pre-B cell development in the absence of surrogate light chains. |
| Breeding history | Backcrossed to BALB/c for at least 12 generations. Currently bred as homozygous. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Allelic exclusion in transgenic mice expressing a heavy chain disease-like human mu protein.;Corcos D, Iglesias A, Dunda O, Bucchini D, Jami J, ;1991;European journal of immunology;21;2711-6; 1936120
- Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein.;Corcos D, Dunda O, Butor C, Cesbron J Y, Lorès P, Bucchini D, Jami J, ;1995;Current biology : CB;5;1140-8; 8548286
- Expression of a V region-less B cell receptor confers a tolerance-like phenotype on transgenic B cells.;Corcos D, Grandien A, Vazquez A, Dunda O, Lorès P, Bucchini D, ;2001;Journal of immunology (Baltimore, Md. : 1950);166;3083-9; 11207259
- The role of the B cell receptor V region in peripheral B cell survival.;Rosado M M, Freitas A A, ;1998;European journal of immunology;28;2685-93; 9754556