MGI phenotypes (allele matching)
B6.129-Zfp110tm1Mpin/Cnrm
| Status | Available to order |
| EMMA ID | EM:00138 |
| International strain name | B6.129-Zfp110tm1Mpin/Cnrm |
| Alternative name | Nrif1-mut. |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Zfp110tm1Mpin, |
| Gene/Transgene symbol | Zfp110 |
Information from provider
| Provider | Elisabeth Casademunt |
| Provider affiliation | Max Planck Inst. of Neurobiology |
| Genetic information | pGK-neo cassette replacing part of the last exon of the Zfp110 (Nrif1) gene. Replacement eliminates the putative p75 receptor-binding region of the ZFP110 (NRIF1) protein. |
| Phenotypic information | In a mixed B6129 background there are no major anatomical defects. However, the following traits have been observed: decrease in apoptotic levels in embryonic retina; abnormal whisker pad innervation; altered NFkB activation in Schwann cells; remarkable decrease in testis size (up to 70% in adults); slightly altered heat sensitivity. The mutation is embryonically lethal in a congenic B6 strain: homozygous mutant embryos do not survive beyond E12.5 |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death.;Casademunt E, Carter B D, Benzel I, Frade J M, Dechant G, Barde Y A, ;1999;The EMBO journal;18;6050-61; 10545116