C57BL/6N-Cdk6tm1c(EUCOMM)Wtsi/TcpBiat
Status | Available to order |
EMMA ID | EM:13810 |
International strain name | C57BL/6N-Cdk6tm1c(EUCOMM)Wtsi/TcpBiat |
Alternative name | C57BL/6N-Cdk6 |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Cdk6tm1c(EUCOMM)Wtsi |
Gene/Transgene symbol | Cdk6 |
Information from provider
Provider | Veronika Sexl |
Provider affiliation | Department of Biomedical Sciences, University of Veterinary Medicine |
Genetic information | The mouse line C57BL/6N-Cdk6tm1c(EUCOMM)Wtsi/Tcp (referred to as Cdk6fl/fl) was generated with C57BL/6N-Cdk6tm1a(EUCOMM)Wtsi/Tcp (available at the Canadian Mouse Mutant Repository (CMMR) at http://www.cmmr.ca/order.php?t=m&id=1766) made from EUCOMM ES cells (Bradley A, Anastassiadis K, Ayadi A, et al. The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome. 2012;23(9-10):580-586) at the Toronto Centre for Phenogenomics, Canada. |
Phenotypic information | Homozygous:No data available; no phenotype expected;Heterozygous:No data available; no phenotype expected; |
Breeding history | Flp excision by breeding a heterozygous male C57BL/6N-Cdk6tm1a(EUCOMM)Wtsi/Tcp with heterozygous C57BL/6N-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Tcp female(s). The mouse line was established by backcrossing Cdk6tm1c+/-; Flp+/- mice to C57BL/6NCrl (less than 10 gen.). |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Animals used for archiving | homozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive primary microcephaly / Orphanet_2512
Literature references
- Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system.;Maurer Barbara, Brandstoetter Tania, Kollmann Sebastian, Sexl Veronika, Prchal-Murphy Michaela, ;2021;Haematologica;106;2624-2632; 32855282
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