C57BL/6N-Il6ra^{em1(IMPC)Wtsi}/WtsiOulu

Status	Available to order
EMMA ID	EM:13825
Citation information	RRID:IMSR_EM:13825 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Il6ra^{em1(IMPC)Wtsi}/WtsiOulu
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Il6ra^{em1(IMPC)Wtsi}
Gene/Transgene symbol	Il6ra

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	University of Oulu, Oulu, Finland

Disease and phenotype information

IMPC phenotypes (allele matching)

increased red blood cell distribution width / IMPC

IMPC phenotypes (gene matching)

increased red blood cell distribution width / IMPC

MGI phenotypes (gene matching)

abnormal inflammatory response / MGI
liver inflammation / MGI
no abnormal phenotype detected / MGI
decreased tumor growth/size / MGI
increased hepatocyte apoptosis / MGI
decreased hepatocyte proliferation / MGI
decreased incidence of tumors by chemical induction / MGI
abnormal wound healing / MGI
decreased susceptibility to parasitic infection / MGI
increased circulating aspartate transaminase level / MGI
growth/size/body region phenotype / MGI
abnormal CD4-positive, alpha-beta T cell physiology / MGI
decreased circulating tumor necrosis factor level / MGI
decreased circulating interleukin-1 beta level / MGI
abnormal circulating serum amyloid protein level / MGI
decreased susceptibility to parasitic infection induced morbidity/mortality / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.

INFRAFRONTIER^® and European Mouse Mutant Archive - EMMA^® are registered trademarks at the European Union Intellectual Property Office (EUIPO).

C57BL/6N-Il6raem1(IMPC)Wtsi/WtsiOulu