IMPC phenotypes (allele matching)
- increased circulating magnesium level / IMPC
C57BL/6N-Ifih1em1(IMPC)Wtsi/WtsiCnbc
| Status | Available to order |
| EMMA ID | EM:13835 |
| Citation information | RRID:IMSR_EM:13835 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Ifih1em1(IMPC)Wtsi/WtsiCnbc |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Ifih1em1(IMPC)Wtsi |
| Gene/Transgene symbol | Ifih1 |
Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6N males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Singleton-Merten dysplasia / Orphanet_85191
- Aicardi-Goutières syndrome / Orphanet_51
IMPC phenotypes (gene matching)
- increased circulating magnesium level / IMPC
MGI phenotypes (gene matching)
- abnormal leukocyte cell number / MGI
- increased granulocyte number / MGI
- mixed cellular infiltration to dermis / MGI
- postnatal growth retardation / MGI
- abnormal T cell activation / MGI
- autoimmune response / MGI
- increased inflammatory response / MGI
- liver inflammation / MGI
- postnatal lethality / MGI
- abnormal dendritic cell physiology / MGI
- increased susceptibility to viral infection / MGI
- abnormal dendritic cell antigen presentation / MGI
- increased immunoglobulin level / MGI
- increased IgG level / MGI
- increased IgM level / MGI
- increased IgA level / MGI
- glomerulonephritis / MGI
- abnormal cytokine secretion / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased susceptibility to systemic lupus erythematosus / MGI
- skin inflammation / MGI
- increased macrophage cell number / MGI
- abnormal cell physiology / MGI
- increased plasma cell number / MGI
- increased dendritic cell number / MGI
- decreased interferon-alpha secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal cytokine level / MGI
- abnormal chemokine level / MGI
- abnormal interferon level / MGI
- abnormal interleukin level / MGI
- decreased survivor rate / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal macrophage activation involved in immune response / MGI