MGI phenotypes (allele matching)
B6;129P2-Men1tm1.1Zqw/Orl
| Status | Available to order |
| EMMA ID | EM:01387 |
| International strain name | B6;129P2-Men1tm1.1Zqw/Orl |
| Alternative name | Men1+/delE3 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Men1tm1.1Zqw, |
| Gene/Transgene symbol | Men1 |
Information from provider
| Provider | Philippe Bertolino |
| Provider affiliation | Laboratoire Génétique Moléculaire, Signalisation et Cancer, CNRS, UMR5201, Universté Claude Bern |
| Genetic information | The Men1 constitutively deleted allele (tm1.1Zqw) was derived from the Men1 conditionally targeted allele (tm1Zqw, see descriptions of EMMA strains EM:01384 and EM:01386) by transfection of targeted ES cells with a cre recombinase-expressing plasmid (pMC-Cre). The neo gene, TK gene, and exon 3 were therefore removed by cre-mediated recombination, resulting in the disruption of the Men1 open reading frame, which is not functional in mice. |
| Phenotypic information | The Men1 null embryos are lethal at E11.5 to E13.5 and display neural tube disclosure, abnormalities in the liver and in heart development. The heterozygous Men1 mice develop hyperplastic lesions at 8 months and multiple endocrine tumours starting from 12 months. |
| Breeding history | This strain is always maintained, even currently, by inbred cross (+/delE3 X +/delE3), and has never been backcrossed or outcrossed. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pituitary gigantism / Orphanet_99725
- Familial isolated hyperparathyroidism / Orphanet_99879
- Multiple endocrine neoplasia type 1 / Orphanet_652
Literature references
- Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs.;Bertolino Philippe, Radovanovic Ivan, Casse Huguette, Aguzzi Adriano, Wang Zhao-Qi, Zhang Chang-Xian, ;2003;Mechanisms of development;120;549-60; 12782272
- Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1.;Bertolino Philippe, Tong Wei-Min, Galendo Dominique, Wang Zhao-Qi, Zhang Chang-Xian, ;2003;Molecular endocrinology (Baltimore, Md.);17;1880-92; 12819299