IMPC phenotypes (gene matching)
STOCK Rgs4tm1.1Jbr/Orl
| Status | Available to order |
| EMMA ID | EM:01388 |
| Citation information | RRID:IMSR_EM:01388 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Rgs4tm1.1Jbr/Orl |
| Alternative name | Rgs4lacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rgs4tm1.1Jbr |
| Gene/Transgene symbol | Rgs4 |
Information from provider
| Provider | Jean-François Brunet |
| Provider affiliation | CNRS/ Ecole normale supérieure |
| Genetic information | Produced by crossing the Rgs4loxFRTlacZ (see EMMA strain EM:01385) strain with a PGK-cre recombinase-expressing mouse strain. Expresses a Rgs4-lacZ fusion from the Rgs4 locus. |
| Phenotypic information | Subtle coordination deficit. Deficient central integration of pain. |
| Breeding history | Four backcrosses to C57BL/6. |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- decreased body weight / MGI
- impaired coordination / MGI
- abnormal touch/ nociception / MGI
- nervous system phenotype / MGI
- impaired behavioral response to morphine / MGI
- decreased behavioral withdrawal response / MGI
- embryonic lethality between somite formation and embryo turning, incomplete penetrance / MGI
MGI phenotypes (gene matching)
- decreased body weight / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- increased circulating HDL cholesterol level / MGI
- abnormal touch/ nociception / MGI
- no abnormal phenotype detected / MGI
- increased vertical activity / MGI
- no phenotypic analysis / MGI
- nervous system phenotype / MGI
- decreased aggression towards mice / MGI
- increased circulating cholesterol level / MGI
- behavior/neurological phenotype / MGI
- decreased renal plasma flow rate / MGI
- impaired conditioned place preference behavior / MGI
- impaired behavioral response to morphine / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- decreased behavioral withdrawal response / MGI
- increased total body fat amount / MGI
- embryonic lethality between somite formation and embryo turning, incomplete penetrance / MGI
Literature references
- Association and linkage analyses of RGS4 polymorphisms in schizophrenia.;Chowdari Kodavali V, Mirnics Karoly, Semwal Prachi, Wood Joel, Lawrence Elizabeth, Bhatia Triptish, Deshpande Smita N, B K Thelma, Ferrell Robert E, Middleton Frank A, Devlin Bernie, Levitt Pat, Lewis David A, Nimgaonkar Vishwajit L, ;2002;Human molecular genetics;11;1373-80; 12023979
- RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload.;Rogers J H, Tamirisa P, Kovacs A, Weinheimer C, Courtois M, Blumer K J, Kelly D P, Muslin A J, ;1999;The Journal of clinical investigation;104;567-76; 10487771
- Generation and characterization of Rgs4 mutant mice.;Grillet Nicolas, Pattyn Alexandre, Contet Candice, Kieffer Brigitte L, Goridis Christo, Brunet Jean-François, ;2005;Molecular and cellular biology;25;4221-8; 15870291