IMPC phenotypes (allele matching)
- increased bone mineral content / IMPC
C57BL/6N-Pcdh15em1(IMPC)Wtsi/WtsiCnbc
| Status | Available to order |
| EMMA ID | EM:13880 |
| Citation information | RRID:IMSR_EM:13880 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Pcdh15em1(IMPC)Wtsi/WtsiCnbc |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Pcdh15em1(IMPC)Wtsi |
| Gene/Transgene symbol | Pcdh15 |
Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6N males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Usher syndrome type 1 / Orphanet_231169
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
IMPC phenotypes (gene matching)
- increased bone mineral content / IMPC
MGI phenotypes (gene matching)
- abnormal organ of Corti morphology / MGI
- organ of Corti degeneration / MGI
- decreased body size / MGI
- abnormal maternal nurturing / MGI
- ataxia / MGI
- circling / MGI
- bidirectional circling / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- head bobbing / MGI
- impaired swimming / MGI
- impaired righting response / MGI
- impaired balance / MGI
- postnatal growth retardation / MGI
- abnormal reflex / MGI
- deafness / MGI
- no abnormal phenotype detected / MGI
- abnormal cochlear hair cell morphology / MGI
- abnormal cochlear ganglion morphology / MGI
- cochlear ganglion degeneration / MGI
- abnormal otolith morphology / MGI
- enlarged otoliths / MGI
- absent tunnel of Corti / MGI
- abnormal cochlear sensory epithelium morphology / MGI
- cochlear ganglion hypoplasia / MGI
- abnormal pillar cell morphology / MGI
- abnormal organ of Corti supporting cell morphology / MGI
- abnormal Hensen cell morphology / MGI
- cochlear hair cell degeneration / MGI
- cochlear inner hair cell degeneration / MGI
- abnormal cochlear outer hair cell morphology / MGI
- cochlear outer hair cell degeneration / MGI
- abnormal orientation of outer hair cell stereociliary bundles / MGI
- abnormal orientation of inner hair cell stereociliary bundles / MGI
- abnormal cochlear hair cell stereociliary bundle morphology / MGI
- abnormal orientation of cochlear hair cell stereociliary bundles / MGI
- short cochlear hair cell stereocilia / MGI
- abnormal outer hair cell stereociliary bundle morphology / MGI
- decreased outer hair cell stereocilia number / MGI
- abnormal inner hair cell stereociliary bundle morphology / MGI
- fused inner hair cell stereocilia / MGI
- decreased inner hair cell stereocilia number / MGI
- abnormal cochlear hair cell inter-stereocilial links morphology / MGI
- abnormal cochlear hair bundle tip links morphology / MGI
- absent distortion product otoacoustic emissions / MGI
- absent linear vestibular evoked potential / MGI
- head tilt / MGI
- head tossing / MGI
- dystonia / MGI
- hearing/vestibular/ear phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal vestibular saccule morphology / MGI
- absent startle reflex / MGI
- retropulsion / MGI
- abnormal inner hair cell kinocilium morphology / MGI
- abnormal outer hair cell kinocilium morphology / MGI
- abnormal vestibular hair cell kinocilium morphology / MGI
- increased or absent threshold for auditory brainstem response / MGI