strain-details - INFRAFRONTIER

Information from provider

Status	Under development - register interest
EMMA ID	EM:13889
Citation information	RRID:IMSR_EM:13889 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NCrl-Lrig3^{em1(IMPC)Ccpcz}/Ph
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Lrig3^{em1(IMPC)Ccpcz}
Gene/Transgene symbol	Lrig3

Provider	Institute of Molecular Genetics
Provider affiliation	Department of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Disease and phenotype information

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

IMPC phenotypes (allele matching)

abnormal vertebrae morphology / IMPC
abnormal heart morphology / IMPC
enlarged heart / IMPC
abnormal cranium morphology / IMPC
abnormal spleen morphology / IMPC
abnormal thymus morphology / IMPC
enlarged thymus / IMPC
abnormal skeletal muscle morphology / IMPC
abnormal gait / IMPC
male infertility / IMPC
female infertility / IMPC
abnormal skin morphology / IMPC
abnormal digit morphology / IMPC
increased circulating alanine transaminase level / IMPC
decreased circulating alkaline phosphatase level / IMPC
increased kidney weight / IMPC
abnormal heart left ventricle morphology / IMPC
abnormal vertebral arch morphology / IMPC
increased circulating creatine kinase level / IMPC
increased circulating lactate dehydrogenase level / IMPC

IMPC phenotypes (gene matching)

abnormal spleen morphology / IMPC
increased circulating creatine kinase level / IMPC
enlarged heart / IMPC
abnormal gait / IMPC
male infertility / IMPC
enlarged thymus / IMPC
abnormal skin morphology / IMPC
increased circulating lactate dehydrogenase level / IMPC
increased kidney weight / IMPC
increased circulating alanine transaminase level / IMPC
abnormal heart morphology / IMPC
abnormal digit morphology / IMPC
abnormal cranium morphology / IMPC
abnormal thymus morphology / IMPC
abnormal skeletal muscle morphology / IMPC
female infertility / IMPC
abnormal vertebral arch morphology / IMPC
abnormal heart left ventricle morphology / IMPC
decreased circulating alkaline phosphatase level / IMPC
abnormal vertebrae morphology / IMPC

MGI phenotypes (gene matching)

abnormal lateral semicircular canal morphology / MGI
decreased circulating HDL cholesterol level / MGI
abnormal craniofacial morphology / MGI
short snout / MGI
decreased body weight / MGI
decreased body size / MGI
circling / MGI
increased heart rate / MGI
decreased circulating insulin level / MGI
increased systemic arterial blood pressure / MGI
no phenotypic analysis / MGI
decreased lateral semicircular canal size / MGI
decreased posterior semicircular canal size / MGI
decreased cardiac output / MGI
decreased circulating glycerol level / MGI
abnormal heart left ventricle morphology / MGI
abnormal ear development / MGI
head tossing / MGI
hearing/vestibular/ear phenotype / MGI
decreased cardiac stroke volume / MGI
abnormal heart left ventricle weight / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

C57BL/6NCrl-Lrig3^{em1(IMPC)Ccpcz}/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Lrig3em1(IMPC)Ccpcz/Ph

Information from provider

Information from EMMA

Disease and phenotype information

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

C57BL/6NCrl-Lrig3^{em1(IMPC)Ccpcz}/Ph