- abnormal aorta morphology / MGI
- abnormal head morphology / MGI
- abnormal blood vessel morphology / MGI
- poor circulation / MGI
- abnormal apoptosis / MGI
- hemorrhage / MGI
- intraventricular hemorrhage / MGI
- abnormal neuron morphology / MGI
- abnormal vitelline vasculature morphology / MGI
- abnormal cardinal vein morphology / MGI
- hemopericardium / MGI
- decreased heart rate / MGI
- abnormal vascular endothelial cell morphology / MGI
- increased vascular endothelial cell number / MGI
- hematoma / MGI
- decreased embryo weight / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- abnormal telencephalon development / MGI
B6.129-Braftm1Zim/Cnrm
Status | Available to order |
EMMA ID | EM:01389 |
International strain name | B6.129-Braftm1Zim/Cnrm |
Alternative name | Braf Knock-out |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Braftm1Zim, |
Gene/Transgene symbol | Braf |
Information from provider
Provider | Leszek Wojnowski |
Provider affiliation | University Mainz |
Genetic information | See Wojnowski et al., Endothelial apoptosis in Braf-deficient mice. Nature Genetics, 16: 293-297 (1997) |
Phenotypic information | Mid-gestational lethality, due to defective angiogenesis. |
References |
|
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pilomyxoid astrocytoma / Orphanet_251615
- Classic hairy cell leukemia / Orphanet_58017
- Craniopharyngioma / Orphanet_54595
- Differentiated thyroid carcinoma / Orphanet_146
- Langerhans cell histiocytosis / Orphanet_389
- Cardiofaciocutaneous syndrome / Orphanet_1340
- Noonan syndrome with multiple lentigines / Orphanet_500
- Syringocystadenoma papilliferum / Orphanet_840
MGI phenotypes (allele matching)
Literature references
- Endothelial apoptosis in Braf-deficient mice.;Wojnowski L, Zimmer A M, Beck T W, Hahn H, Bernal R, Rapp U R, Zimmer A, ;1997;Nature genetics;16;293-7; 9207797
- Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.;Wojnowski L, Stancato L F, Larner A C, Rapp U R, Zimmer A, ;2000;Mechanisms of development;91;97-104; 10704835
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).