B6.129-Ntn1Gt(IRESBetageo)1Pgr/Cnrm

Status

Available to order

EMMA IDEM:00139
International strain nameB6.129-Ntn1Gt(IRESBetageo)1Pgr/Cnrm
Alternative nameNtn1-gt
Strain typeGene-trap
Allele/Transgene symbolNtn1Gt(IRESBetageo)1Pgr,
Gene/Transgene symbolNtn1

Information from provider

ProviderPeter Gruss
Provider affiliationMax Planck Inst. Biophysical Chemistry
Genetic informationInsertion of the IRES-geo vector into the netrin 1 locus.
Phenotypic informationMutants lack two inner ear semicircular canals.
Breeding historyBackcrossed to C57BL/6 (more than 7 backcross generations).
References
  • Netrin 1 is required for semicircular canal formation in the mouse inner ear.;Salminen M, Meyer B I, Bober E, Gruss P, ;2000;Development (Cambridge, England);127;13-22; 10654596

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal brain commissure morphology / MGI
  • abnormal inner ear canal fusion / MGI
  • absent lateral semicircular canal / MGI
  • absent posterior semicircular canal / MGI
  • absent gastric milk in neonates / MGI
  • perinatal lethality, complete penetrance / MGI

Literature references

  • Netrin 1 is required for semicircular canal formation in the mouse inner ear.;Salminen M, Meyer B I, Bober E, Gruss P, ;2000;Development (Cambridge, England);127;13-22; 10654596

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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