NOD.B6-(D1Mit15-D1Mit359)/GhjCnrm
| Status | Available to order |
| EMMA ID | EM:01396 |
| International strain name | NOD.B6-(D1Mit15-D1Mit359)/GhjCnrm |
| Alternative name | NOD.B6-C1D(L2) |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Fcgr2b, |
| Gene/Transgene symbol | Fcgr2b |
Information from provider
| Provider | Henri-Jean Garchon |
| Provider affiliation | ER70 CNRS et Unite 125 Inserm |
| Genetic information | NOD congenic strain with the distal chromosome 1 from C57BL/6 (line 2). |
| Phenotypic information | This line bears the main QTL controlling serum levels of IgG1 and IgG2b in NOD mice. The main candidate is the Fcgr2 gene that codes for the low affinity type 2 receptor for IgG, whose expression is decreased by 90% in macrophages. This same interval also controls the severity of experimental arthritis, the number and the function of natural killer T cells, IgE serum levels, and an increased resistance to endotoxin shock. |
| Breeding history | 20 generations of backcrosses followed by sister-brother matings. Selection of subcongenics by additional backcrosses. |
| References | None available |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |