FVB-Tg(ACTB-tTS)1Mllo/Cnrm
| Status | Available to order |
| EMMA ID | EM:01415 |
| Citation information | RRID:IMSR_EM:01415 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB-Tg(ACTB-tTS)1Mllo/Cnrm |
| Alternative name | pAct-tTS |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(ACTB-tTS)1Mllo |
| Gene/Transgene symbol | Tg(ACTB-tTS)1Mllo |
Information from provider
| Provider | Moises Mallo |
| Provider affiliation | Instituto Gulbenkian de Ciencia |
| Genetic information | The tTS molecule (a hybrid between the tetracycline repressor, tetR and the KRAB transcriptional repressor) is expressed ubiquitously under the human beta-actin promoter. The construct also contains insulator sequences from the chicken globin locus. This is a transgenic strain to be used in a dual control system to allow repression from promoters carrying tetO (tetracycline operator) sequences. It can be used to produce reversible gene inactivation from tetO-modified loci or to repress the leakiness of tetO promoters when using the tet-ON system. |
| Phenotypic information | There are no defects associated to this strain. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Reversible gene inactivation in the mouse.;Mallo Moisés, Kanzler Benoît, Ohnemus Sabine, ;2003;Genomics;81;356-60; 12676559