FVB-Tg(ACTB-tTS)1Mllo/Cnrm
| Status | Available to order |
| EMMA ID | EM:01415 |
| International strain name | FVB-Tg(ACTB-tTS)1Mllo/Cnrm |
| Alternative name | pAct-tTS |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(ACTB-tTS)1Mllo, |
| Gene/Transgene symbol | Tg(ACTB-tTS)1Mllo |
Information from provider
| Provider | Moises Mallo |
| Provider affiliation | Instituto Gulbenkian de Ciencia |
| Genetic information | The tTS molecule (a hybrid between the tetracycline repressor, tetR and the KRAB transcriptional repressor) is expressed ubiquitously under the human beta-actin promoter. The construct also contains insulator sequences from the chicken globin locus. This is a transgenic strain to be used in a dual control system to allow repression from promoters carrying tetO (tetracycline operator) sequences. It can be used to produce reversible gene inactivation from tetO-modified loci or to repress the leakiness of tetO promoters when using the tet-ON system. |
| Phenotypic information | There are no defects associated to this strain. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Reversible gene inactivation in the mouse.;Mallo Moisés, Kanzler Benoît, Ohnemus Sabine, ;2003;Genomics;81;356-60; 12676559