- decreased bone mineral density / IMPC
- decreased circulating LDL cholesterol level / IMPC
- decreased circulating HDL cholesterol level / IMPC
- enlarged heart / IMPC
- thin ventricular wall / IMPC
- abnormal tibia morphology / IMPC
- abnormal spleen morphology / IMPC
- convulsive seizures / IMPC
- decreased body length / IMPC
- abnormal lens morphology / IMPC
- cataract / IMPC
- hyperactivity / IMPC
- hypoactivity / IMPC
- decreased startle reflex / IMPC
- limb grasping / IMPC
- increased vertical activity / IMPC
- decreased circulating triglyceride level / IMPC
- increased heart weight / IMPC
- decreased hemoglobin content / IMPC
- decreased circulating alkaline phosphatase level / IMPC
- increased circulating chloride level / IMPC
- abnormal bone structure / IMPC
- increased lean body mass / IMPC
- decreased lean body mass / IMPC
- abnormal behavior / IMPC
- decreased spleen weight / IMPC
- decreased circulating cholesterol level / IMPC
- improved glucose tolerance / IMPC
- decreased circulating serum albumin level / IMPC
- decreased cornea thickness / IMPC
- increased circulating creatinine level / IMPC
- decreased circulating creatinine level / IMPC
- decreased circulating glucose level / IMPC
- decreased circulating total protein level / IMPC
- increased cardiac muscle contractility / IMPC
- increased circulating sodium level / IMPC
- decreased mean corpuscular hemoglobin concentration / IMPC
- increased NK cell number / IMPC
- decreased prepulse inhibition / IMPC
- decreased total body fat amount / IMPC
- decreased grip strength / IMPC
- increased red blood cell distribution width / IMPC
- increased bone mineral content / IMPC
- decreased bone mineral content / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- abnormal behavioral response to light / IMPC
- abnormal sleep behavior / IMPC
- increased fluid intake / IMPC
- decreased total retina thickness / IMPC
- increased or absent threshold for auditory brainstem response / IMPC
- increased KLRG1-positive NK cell number / IMPC
C57BL/6N-Rnf10tm1b(KOMP)Wtsi/WtsiPh
Status | Under development - register interest |
EMMA ID | EM:14178 |
International strain name | C57BL/6N-Rnf10tm1b(KOMP)Wtsi/WtsiPh |
Alternative name | EPD0025_2_A10 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Rnf10tm1b(KOMP)Wtsi, |
Gene/Transgene symbol | Rnf10 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from KOMP ES clone EPD0025_2_A10. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele using a cell permeable HTN-Cre as described in doi:10.1007/s11248-013-9764-x. Click here for more information on KOMP final vectors. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
IMPC phenotypes (allele matching)
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