IMPC phenotypes (allele matching)
- preweaning lethality, complete penetrance / IMPC
C57BL/6N-Adamts3tm1b(KOMP)Wtsi/WtsiH
| Status | Only small colony available |
| EMMA ID | EM:14183 |
| International strain name | C57BL/6N-Adamts3tm1b(KOMP)Wtsi/WtsiH |
| Alternative name | EPD0660_2_C10 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Adamts3tm1b(KOMP)Wtsi, |
| Gene/Transgene symbol | Adamts3 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from KOMP ES clone EPD0660_2_C10. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele using an X-linked CMV-Cre driver (EM:05414; C57BL/6N-Hprttm1(CMV-cre)Wtsi/WtsiOulu) for this purpose. Click here for more information on KOMP final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hennekam syndrome / Orphanet_2136
MGI phenotypes (allele matching)
- cleft palate / MGI
- double outlet right ventricle / MGI
- abnormal forebrain morphology / MGI
- abnormal lateral ventricle morphology / MGI
- abnormal third ventricle morphology / MGI
- abnormal fourth ventricle morphology / MGI
- abnormal hindbrain morphology / MGI
- aorta coarctation / MGI
- bifid ureter / MGI
- dilated ureter / MGI
- abnormal Mullerian duct morphology / MGI
- abnormal Wolffian duct morphology / MGI
- abnormal adenohypophysis morphology / MGI
- basisphenoid bone foramen / MGI
- fusion of vertebral arches / MGI
- absent stapedial artery / MGI
- hemopericardium / MGI
- abnormal cervical rib / MGI
- thoracoschisis / MGI
- abnormal liver parenchyma morphology / MGI
- abnormal optic chiasm morphology / MGI
- perimembraneous ventricular septal defect / MGI
- abnormal vertebral artery morphology / MGI
- dual inferior vena cava / MGI
- abnormal basilar artery morphology / MGI
- absent segment of anterior cerebral artery / MGI
- retropleural edema / MGI
- subcutaneous edema / MGI
- abnormal Mullerian duct topology / MGI
- abnormal vitelline vein connection / MGI
- trigeminal neuroma / MGI
- absent ductus venosus valve / MGI
- abnormal ductus venosus valve morphology / MGI
- abnormal ductus venosus valve topology / MGI
- multiple persisting craniopharyngeal ducts / MGI
- abnormal vitelline vein topology / MGI
- persistent dorsal ophthalmic artery / MGI
- embryo cyst / MGI
- heterochrony / MGI