- decreased circulating LDL cholesterol level / IMPC
- decreased circulating calcium level / IMPC
- decreased leukocyte cell number / IMPC
- decreased monocyte cell number / IMPC
- decreased body length / IMPC
- abnormal gait / IMPC
- stereotypic behavior / IMPC
- trunk curl / IMPC
- impaired righting response / IMPC
- increased mean corpuscular volume / IMPC
- decreased circulating triglyceride level / IMPC
- decreased circulating insulin level / IMPC
- increased circulating chloride level / IMPC
- abnormal bone structure / IMPC
- increased lean body mass / IMPC
- decreased lean body mass / IMPC
- decreased eosinophil cell number / IMPC
- increased T cell number / IMPC
- decreased B cell number / IMPC
- decreased circulating glucose level / IMPC
- increased mean corpuscular hemoglobin / IMPC
- increased circulating sodium level / IMPC
- absent pinna reflex / IMPC
- increased NK cell number / IMPC
- increased CD4-positive, alpha beta T cell number / IMPC
- increased CD8-positive, alpha-beta T cell number / IMPC
- decreased mature B cell number / IMPC
- decreased total body fat amount / IMPC
- increased bone mineral content / IMPC
- decreased bone mineral content / IMPC
- decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- increased alpha-beta T cell number / IMPC
- decreased Ly6C high monocyte number / IMPC
- decreased Ly6C low monocyte number / IMPC
- decreased fasted circulating glucose level / IMPC
C57BL/6N-Cdh23tm2b(EUCOMM)Wtsi/WtsiH
Status | Only small colony available |
EMMA ID | EM:14252 |
International strain name | C57BL/6N-Cdh23tm2b(EUCOMM)Wtsi/WtsiH |
Alternative name | MEPD1008_2_A03 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Cdh23tm2b(EUCOMM)Wtsi |
Gene/Transgene symbol | Cdh23 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone MEPD1008_2_A03. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele using a cell permeable HTN-Cre as described in doi:10.1007/s11248-013-9764-x. Click here for more information on EUCOMM final vectors. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Usher syndrome type 1 / Orphanet_231169
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
IMPC phenotypes (allele matching)
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