- decreased circulating creatinine level / IMPC
- decreased mean corpuscular hemoglobin / IMPC
- decreased effector memory CD4-positive, alpha-beta T cell number / IMPC
- decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
- increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
C57BL/6N-Il27tm1b(EUCOMM)Wtsi/WtsiH
Status | Only small colony available |
EMMA ID | EM:14345 |
International strain name | C57BL/6N-Il27tm1b(EUCOMM)Wtsi/WtsiH |
Alternative name | MEPD1009_2_F02 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Il27tm1b(EUCOMM)Wtsi |
Gene/Transgene symbol | Il27 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone MEPD1009_2_F02. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele using a cell permeable HTN-Cre as described in doi:10.1007/s11248-013-9764-x. Click here for more information on EUCOMM final vectors. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (allele matching)
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